Jahnavi Aluri

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Severe combined immunodeficiency (SCID) represents a heterogenous group of disorders that affects both the cell mediated and humoral immunity. In an atypical presentation of SCID, an abnormal T-cell receptor (TCR) signalingdue to ZAP70 deficiency results in recurrent bacterial, viral, and opportunistic infections, diarrhea, and failure to thrive [1]. This(More)
Prolonged excretion of poliovirus can occur in immunodeficient patients who receive oral polio vaccine, which may lead to propagation of highly divergent vaccine-derived polioviruses (VDPVs), posing a concern for global polio eradication. This study aimed to estimate the proportion of primary immunodeficient children with enterovirus infection and to(More)
Severe combined immunodeficiency (SCID) is one of the most severe and fatal forms of inherited primary immunodeficiency. Early diagnosis of SCID improves the outcome of life before and after hematopoietic stem cell transplant (HSCT). SCID fulfills the internationally-established criteria for a condition to be screened for at birth. T cell receptor excision(More)
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