Jagdish Chandra

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A divide-and-conquer implementation of a generalized Schur algorithm enables (exact and) least-squares solutions of various block-Toeplitz or Toeplitz-block systems of equations with O(can log 2 n) operations to be obtained, where the displacement rank a is a small constant (typically between two to four for scalar near-Toeplitz matrices) independent of the(More)
OBJECTIVE To study clinical profiles and outcome of children of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) during 1996 Delhi epidemic. DESIGN Retrospective study. SETTING Hospital based study. METHODS Children hospitalized from September to November 1996 were studied. All patients were diagnosed, managed and monitored according to(More)
The proteasome has emerged as an important clinically relevant target for the treatment of hematologic malignancies. Since the Food and Drug Administration approved the first-in-class proteasome inhibitor bortezomib (Velcade) for the treatment of relapsed/refractory multiple myeloma (MM) and mantle cell lymphoma, it has become clear that new inhibitors are(More)
OBJECTIVE To look for profile of severe malaria and contribution of vivax infection to malarial morbidity in North Indian children. METHODS Detailed clinical, biochemical and hematological characteristics of children hospitalized with severe malaria over last 3 y were recorded. Presence of malarial parasite on peripheral smear and/or positive antigen test(More)
OBJECTIVE To evaluate simple clinical signs of illness in young infants (0 to 2 months) and to correlate with WHO IMCI algorithm (7 days-2 months). DESIGN Prospective observational. Study conducted in the outpatient department and emergency room of a pediatric tertiary level hospital. METHODS Four hundred and ninety seven young infants (0 to 2 months)(More)
BACKGROUND The p53 tumor suppressor gene is mutated in up to 70% of pancreatic adenocarcinomas. We determined the effect of reintroduction of the wild-type p53 gene on proliferation and apoptosis in human pancreatic cancer cells using an adenoviral vector containing the wild-type p53 tumor suppressor gene. METHODS Transduction efficiencies of six(More)
1182 Indian Journal of Pediatrics, Volume 76—November, 2009 complications2 and exclusion of mild cases. Thus a survival rate of 69% appears highly encouraging, despite selection-bias skewed towards critically ill patients and presence of poor prognostic factors viz., leukocytosis, lifethreatening dyselectrolytemias, neurological and abdominal complications.(More)
Recent work has demonstrated that glucocorticoids, nucleoside analogues, and other cancer chemotherapeutics induce apoptosis in chronic lymphocytic leukemia (CLL) cells. In this study, we investigated the involvement of protease activation in these responses using selective peptide inhibitors of the interleukin-1beta converting enzyme (ICE)/caspase family(More)
To study pulmonary function tests (PFT) in multiple transfusion recipient thalassemics, PFTs were done for 30 thalassemics and 20 matched controls. Confirmed cases of thalassemia on regular transfusion therapy were the subject of study. Apart from history and physical examination of the thalassemics, serum ferritin estimation and spirometry were done.(More)