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Objective Soluble guanylyl cyclase, (sGC) is an enzyme that can be activated endogenously by nitric oxide (NO). As its particulate counterparts, the role of the cytoplasmic sGC inside the cell is to convert GTP to the second messenger, cGMP. NO is produced by nitric oxide synthase during the conversion of l-arginine to l-citrulline. NO binds to the ferrous… (More)