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Following the previous SAR of a novel dihydropyrimidinone scaffold as HIV-1 replication inhibitors a detailed study directed towards optimizing the metabolic stability of the ester functional group in the dihydropyrimidinone (DHPM) scaffold is described. Replacement of the ester moiety by thiazole ring significantly improved the metabolic stability while(More)
A total of 140,000 compounds were screened in a targetfree cell-based high throughput assay against HIV-1 infection, and a subset of 81 promising compounds was identified. Secondary screening of these 81 compounds revealed two putative human RNaseH2 inhibitors, RHI001 and RHI002, with IC50 value of 6.8 μM and 16 μM, respectively. RHI002 showed selective(More)
As the rate of use, VDOT engineers recognized the need for additional engineering analysis and design functionalities. In response, five geotechnical engineering applications used to calculate slope stability and foundation pile capacity were identified. Analysis and Design Modules (ADM) for these five applications were designed, developed, and implemented(More)
A novel application of web-based virtual laboratories to prepare students for physical experiments is explored in some detail. The pedagogy of supplementing physical laboratory with web-based virtual laboratories is implemented by developing a web-based tool, designated in this work as " eLIVE " , an acronym for Engineering Laboratory Instruction in Virtual(More)
An Internet-based, spatiotemporal Geotechnical Database Management System (GDBMS) Framework was implemented at the Virginia Department of Transportation (VDOT) in 2002 to manage geotechnical data using a distributed Geographical Information System (GIS) methodology. GDBMS Framework was initially envisioned as a tool for archiving and accessing geotechnical(More)
We identified a novel class of aryl-substituted triazine compounds as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) during a high-throughput screening campaign that evaluated more than 200000 compounds for antihuman immunodeficiency virus (HIV) activity using a cell-based full replication assay. Herein, we disclose the optimization of the(More)
The applications of the Knowledge-Based engineering has emerged as a potential technique for incorporating human expertise and some degree of intelligent judgment into decision-supporting procedures. An Expert Knowledge Base (EKB) methodology to estimate the volume and hydrograph of direct surface runoff from rain events using Soil Conservation Service(More)
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