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Journals and Conferences
Gold nanoparticles (GNPs) have gained significant interest as nanovectors for combined imaging and photothermal therapy of tumors. Delivered systemically, GNPs preferentially accumulate at the tumor site via the enhanced permeability and retention effect, and when irradiated with near infrared light, produce sufficient heat to treat tumor tissue. The… (More)
Gold nanoshells (GNS) are a new class of nanoparticles that can be optically tuned to scatter or absorb light from the near-ultraviolet to near-infrared (NIR) region by varying the core (dielectric silica)/shell (gold) ratio. In addition to spectral tunability, GNS are inert and bioconjugatable, making them potential labels for in vivo imaging and therapy… (More)
We report strong two-photon-induced photoluminescence (TPIP) from silica/gold nanoshells (NS). We demonstrate its potential application for imaging the 3D distribution of NS in tumors using a NIR laser scanning multi-photon microscope.
BACKGROUND AND OBJECTIVES: Gold nanoparticles (GNPs) such as gold nanoshells (GNSs) and gold nanorods (GNRs) have been explored in a number of in vitro and in vivo studies as imaging contrast and cancer therapy agents due to their highly desirable spectral and molecular properties. While the organ-level biodistribution of these particles has been reported… (More)
We report the nonlinear photo-physical properties of silica/gold nanoshells (NS) and demonstrate their application as biological imaging agents. We present images of the microscopic distribution of nanoshells in murine tumors using NIR laser scanning multi-photon microscopy.