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Inhibition of osteoclast differentiation and bone resorption by rotenone, through down-regulation of RANKL-induced c-Fos and NFATc1 expression.
TLDR
It is suggested that rotenone demonstrated inhibitory effects on osteoclast differentiation in vitro and suppressed inflammatory bone loss in vivo and may therefore serve as a useful drug in the prevention of bone loss. Expand
Emodin Regulates Bone Remodeling by Inhibiting Osteoclastogenesis and Stimulating Osteoblast Formation
TLDR
It is shown here that emodin is a potential target for osteoporosis therapeutics, as treatment with this agent enhances osteoblast differentiation and bone growth and suppresses osteoclast differentiate and bone resorption. Expand
Anabolic activity of ursolic acid in bone: Stimulating osteoblast differentiation in vitro and inducing new bone formation in vivo.
TLDR
It is demonstrated that the ubiquitous plant triterpenoid, ursolic acid, enhances differentiation and mineralization of osteoblasts in vitro and has the anabolic potential to stimulate osteoblast differentiation and enhance new bone formation. Expand
Harpagoside Inhibits RANKL-Induced Osteoclastogenesis via Syk-Btk-PLCγ2-Ca(2+) Signaling Pathway and Prevents Inflammation-Mediated Bone Loss.
TLDR
Harpagoside inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis in vitro and suppresses inflammation-induced bone loss in a mouse model, suggesting that HAR is a valuable agent against inflammation-related bone disorders but not osteoporosis induced by hormonal abnormalities. Expand
Nicotinamide phosphoribosyltransferase inhibits receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation in vitro
TLDR
It is demonstrated that Nampt acts as a negative regulator of RANKL-mediated differentiation of BMMs into osteoclasts, suggesting the potential therapeutic targets to treat bone-related disorders such as osteoporosis. Expand
Downregulation of p38 kinase pathway by cAMP response element-binding protein protects HL-60 cells from iron chelator-induced apoptosis.
TLDR
Results demonstrate that cAMP-dependent CREB activation plays an important role in protecting HL-60 cells from iron chelator-induced apoptosis, presumably through downregulation of p38 kinase. Expand
Effect of Cornus Officinalis on Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL)-induced Osteoclast Differentiation
TLDR
The results suggest that cornus officinalis may be a useful the treatment of osteoporosis. Expand
Anti-inflammatory activity of fisetin in human mast cells (HMC-1).
TLDR
Fisetin suppressed powerful induction of NF-kappaB promoter-mediated luciferase activity and inhibited p38 mitogen-activated protein kinase, extracellular-regulated Kinase, and c-Jun N-terminal kinase in HMC-1 cells, producing new suggestion that fiset in is a potential medicine for treatment of inflammatory diseases through the down-regulation of mast cell activation. Expand
GM-CSF Regulates Fusion of Mononuclear Osteoclasts into Bone-Resorbing Osteoclasts by Activating the Ras/ERK Pathway1
TLDR
It is demonstrated that GM-CSF induced fusion of pOCs to form multinucleated osteoclasts, making the osteoclast capable of bone resorption. Expand
Chlorogenic acid inhibits osteoclast differentiation and bone resorption by down-regulation of receptor activator of nuclear factor kappa-B ligand-induced nuclear factor of activated T cells c1
TLDR
CGA remarkably attenuated LPS-induced bone loss based on micro-computed tomography and histologic analysis of femurs, suggesting that CGA may be a potential treatment option for osteoclast-related diseases with inflammatory bone destruction. Expand
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