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Yap1 and Skn7 Control Two Specialized Oxidative Stress Response Regulons in Yeast*
TLDR
Remarkably, these two gene subsets separate antioxidant scavenging enzymes from the metabolic pathways regenerating the main cellular reducing power, glutathione and NADPH, and may explain, at least in part, the dissociated function of Yap1 and Skn7 in H2O2 and cadmium resistance. Expand
Biochemical Characterization of the Human Copper Transporter Ctr1*
TLDR
This is the first report on the biochemical characterization of the human copper transporter hCtr1, which is important for understanding mechanisms for mammalian copper transport at the plasma membrane. Expand
The H2O2 Stimulon in Saccharomyces cerevisiae *
TLDR
This study represents the first genome-wide characterization of a H2O2-inducible stimulon in a eukaryote and results in the resetting of carbohydrate metabolism minutes after the exposure to H2 O2. Expand
Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals
TLDR
It is demonstrated that deletion of the yeast CTR1 gene, which encodes a high-affinity copper transporter, results in increased cis platin resistance and reduced intracellular accumulation of cisplatin, and proposed that cisplin uptake is mediated by the copper transporter Ctr1p in yeast and mammals. Expand
A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity*
TLDR
The data suggest that copper-transporting ATPases, CopA and ATP7A, in both bacteria and macrophage are unique determinants of bacteria survival and identify an unexpected role for copper at the host-pathogen interface. Expand
Biochemical and Genetic Analyses of Yeast and Human High Affinity Copper Transporters Suggest a Conserved Mechanism for Copper Uptake*
TLDR
The topological orientation of the yeast Ctr1 copper transport protein is elucidated, showing that a series of clustered methionine residues in the hydrophilic extracellular domain and an MXXXM motif in the second transmembrane domain are important for copper uptake but not for protein sorting and delivery to the cell surface. Expand
Characterization of Mouse Embryonic Cells Deficient in the Ctr1 High Affinity Copper Transporter
TLDR
Observations demonstrate that, although Ctr1 is critical for both cellular copper uptake and embryonic development, mammals possess additional biochemically distinct functional copper transport activities. Expand
Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development
TLDR
It is shown that the mouse Ctr1 gene encodes a component of the Cu transport machinery and that mice heterozygous for Ctr2 exhibit tissue-specific defects in copper accumulation and in the activities of copper-dependent enzymes. Expand
Copper-stimulated Endocytosis and Degradation of the Human Copper Transporter, hCtr1*
TLDR
HCtr1-mediated copper uptake into mammalian cells is regulated by a post-translational mechanism involving copper-stimulated endocytosis and degradation of the transporter, which suggests that intracellular levels of this nutrient must be controlled. Expand
Mobilization of Intracellular Copper Stores by the Ctr2 Vacuolar Copper Transporter*
TLDR
A novel mechanism for copper mobilization is identified and it is suggested that organisms cope with copper deprivation via the use of intracellular vesicular stores and that ctr2Δ mutants hyper-accumulate vacuolar copper. Expand
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