Jaehyun Choi

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Recently, MET exon 14 deletion (METex14del) has been postulated to be one potential mechanism for MET protein overexpression. We screened for the presence of METex14del transcript by multiplexed fusion transcript analysis using nCounter assay followed by confirmation with quantitative reverse transcription PCR with correlation to MET protein expression by(More)
The Met receptor tyrosine kinase is an attractive target for cancer therapy as it promotes invasive tumor growth. SAIT301 is a novel anti-Met antibody, which induces LRIG1-mediated Met degradation and inhibits tumor growth. However, detailed downstream mechanism by which LRIG1 mediates target protein down-regulation is unknown. In the present study, we(More)
The rapid pace of technological advances creates many difficulties for R&D practitioners in analyzing emerging technologies. Patent information analysis is an effective tool in this situation. Conventional patent information analysis has focused on the extraction of vacant, promising, or core technologies and the monitoring of technological trends. From a(More)
c-Met, the high affinity receptor for hepatocyte growth factor (HGF), is one of the most frequently activated tyrosine kinases in many human cancers and a target for cancer therapy. However, inhibitory targeting of c-Met with antibodies has proven difficult, because most antibodies have intrinsic agonist activity. Therefore, the strategy for reducing the(More)
This paper reports on experience inducting subcontractor process ontologies as part of research on the SEEK: Scalable Extraction of Enterprise Knowledge project at the University of Florida. We briefly review approaches to ontology generation and the application of those approaches to product/process ontologies in the AEC arena as well as process-oriented(More)
The configuration management of a sensor network composed of tens or up to thousands of nodes is difficult due to the limit of memory space and energy consumption. This paper presents an approach for dynamic reconfiguration of application modules in sensor networks based on Nano-Qplus. The version information from proposed methods is registered into NVSync(More)
Wireless sensor network consisting of a large number of small sensors is effective for gathering various data in a variety of environments. Since each sensor operates on battery, energy efficient data transfer is indispensable to maximize the lifetime of the network. In this paper we propose a new data transfer protocol employed in large-scale wireless(More)
The packets in the Internet are classified by edge router according to the traffic conditioning agreement (TCA) in differentiated services (DiffServ) domain. The core routers forward the packets in different fashion according to the PHB(Per Hop-Behavior). Currently, the QoS during handover is not guaranteed since packet buffering does not consider PHB(More)
High level of uncertainty is one of the most distinct characteristics of construction operations. This is especially true when it comes to estimating construction operation durations because the operations are performed in the field where unpredictable site conditions may influence production. In order to expedite the modeling, analysis, and optimization of(More)
Despite its grave importance, it is observed that the measurement of quantity estimates in construction sites lacks reliability from the absence of clear standards, letting the estimates to be influenced by factors including the investigator, the participants, the experience of the investigator, field circumstances and field conditions (season). However,(More)