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Relocation mechanisms of the circulating tumor cells (CTCs) from the primary site to the secondary site through the blood vessel network cause tumor metastasis. Despite of the importance to diagnose the cancer metastasis by CTCs, still it is formidable challenge to use in the clinical purpose because of the rarity and the heterogeneity of CTCs in the cancer(More)
Hemophilia A is an X-linked genetic disorder caused by mutations in the F8 gene, which encodes the blood coagulation factor VIII. Almost half of all severe hemophilia A cases result from two gross (140-kbp or 600-kbp) chromosomal inversions that involve introns 1 and 22 of the F8 gene, respectively. We derived induced pluripotent stem cells (iPSCs) from(More)
A novel range-free localization algorithm based on the multidimensional support vector regression (MSVR) is proposed in this paper. The range-free localization problem is formulated as a multidimensional regression problem, and a new MSVR training method is proposed to solve the regression problem. Unlike standard support vector regression, the proposed(More)
Highly homogeneous and functional stem cell-derived hepatocyte-like cells (HLCs) are considered a promising option in the cell-based therapy of liver disease and the development of effective in vitro toxicity screening tools. However, the purity of cells and expression and/or activity of drug metabolizing enzymes in stem cell-derived HLCs are usually too(More)
SUMMARY A new structure learning approach for Bayesian networks (BNs) based on dual genetic algorithm (DGA) is proposed in this paper. An individual of the population is represented as a dual chromosome composed of two chromosomes. The first chromosome represents the ordering among the BN nodes and the second represents the conditional dependencies among(More)
If f is a binary word and d a positive integer, then the generalized Fibonacci cube Q d (f) is the graph obtained from the d-cube Q d by removing all the vertices that contain f as a factor, while the generalized Lucas cube Q d (↽ f) is the graph obtained from Q d by removing all the vertices that have a circulation containing f as a factor. The Fibonacci(More)
The synthesis of pure whitlockite (WH: Ca18Mg2(HPO4)2(PO4)12) has remained a challenge even though it is the second most abundant inorganic in living bone. Although a few reports about the precipitation of WH in heterogeneous phases have been published, to date, synthesizing WH without utilizing any effects of a buffer or various other ions remains(More)