Jae Yoon Park

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BACKGROUND Bone morphogenic proteins (BMPs) are known to promote osteogenesis, and clinical trials are currently underway to evaluate the ability of certain BMPs to promote fracture-healing and spinal fusion. The optimal BMPs to be used in different clinical applications have not been elucidated, and a comprehensive evaluation of the relative osteogenic(More)
Bone formation is presumably a complex and well-orchestrated process of osteoblast lineage-specific differentiation. As members of the TGFbeta superfamily, bone morphogenetic proteins (BMPs) play an important role in regulating osteoblast differentiation and subsequent bone formation. Several BMPs are able to induce de novo bone formation. Although(More)
Genotoxic stresses stabilize the p53 tumor suppressor protein which, in turn, transactivates target genes to cause apoptosis. Although Noxa, a "BH3-only" member of the Bcl-2 family, was shown to be a target of p53-mediated transactivation and to function as a mediator of p53-dependent apoptosis through mitochondrial dysfunction, the molecular mechanism by(More)
The resistance of bioceramics against non-specific adsorption of serum proteins is critical for a wide range of biomedical applications. Some polysaccharides serve as natural protein-resistant molecules in extracellular matrices; however, the stable adhesion of polysaccharides to ceramic biomaterials in an aqueous solution is very challenging because(More)
Cardiovascular disease (CVD) is the main public health problem in patients with chronic kidney disease (CKD); however, there is no established biomarker for predicting CVD morbidity and mortality in CKD. The aim of this study was to evaluate the role of circulating tumor necrosis factor receptors (cTNFRs) in predicting CVD risk in CKD patients.We(More)
AIM Vascular stiffness is associated with cardiovascular mortality in dialysis patients and related with vascular calcification and microvascular inflammation. The objective of this study is to compare predictability of two different vascular calcification scoring systems using plain radiographs in peritoneal dialysis (PD) patients. METHODS Vascular(More)
Small interfering RNA (siRNA) has been considered as a very attractive therapeutic alternative to chemical drugs; however, the chemical and biological instability and poor delivery efficiency of siRNA limit its success in clinical applications. Here we report a protein-resistant, reductively dissociable siRNA delivery system based on self-assembled(More)
Surface modification of inorganic materials to prevent non-specific protein adsorption is critically important for developing a biocompatible materials' platform for medical implantation, diagnostics, and therapeutics. Here we report mussel-inspired chemical modification of dextran for anti-fouling coatings of metal oxide. Catechols are conjugated to(More)
In this paper we introduce an enhanced DQRUMA/ MC-CDMA protocol for wireless packet networks. The original DQRUMA/MC-CDMA protocol may suffer severe code collisions due to a limited number of request codes. An enhanced DQRUMA/MC-CDMA protocol using minislots for request accesses is proposed to reduce request collisions. In the proposed protocol, request(More)
The original Distributed-Queueing Request Update Multiple Access (DQRUMA)/Multi-code (MC) Code Division Multiple Access (CDMA) protocol was developed as a channel access protocol for wireless packet CDMA networks. We modify the original protocol, which was designed for data traffic only, to additionally accommodate voice traffic. We evaluate the performance(More)