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PythDock is a heuristic docking program that uses Python programming language with a simple scoring function and a population based search engine. The scoring function considers electrostatic and dispersion/repulsion terms. The search engine utilizes a particle swarm optimization algorithm. A grid potential map is generated using the shape information of a(More)
The use of light for medical treatment has been studied previously. In this study, we examined the effect of light from a red light-emitting diode on osteogenic differentiation of mouse mesenchymal stem cells (D1 cells) which were cultured in the presence of osteogenic differentiation medium (ODM) for 3 days, then exposed to a red light-emitting diode (LED)(More)
Three dimensional (3D) quantitative structure-activity relationship studies of 37 B-Raf inhibitors, pyrazole-based derivatives, were performed. Based on the co-crystallized compound (PDB ID: 3D4Q), several alignment methods were utilized to derive reliable comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis(More)
The purpose of this study was to evaluate the results of liner cementation into a stable acetabular shell using a metal-inlay polyethylene liner in 39 revision total hip arthroplasties. After an average of 2.8 years, 1 cemented liner dislodged from its metal shell at a postoperative 4 years. In the other 38 hips, mean Harris hip scores improved from 65(More)
PURPOSE The purpose of this study is to present the outcome of sural nerve grafting that focuses on motor fascicles in 6 patients with high radial nerve injuries with defects of more than 9 cm. METHODS Six patients with a high radial nerve complete injury were treated with a sural nerve autograft during a 6-year interval from June 1994 to June 2000. The(More)
As the cost of DNA sequencing decreases, association studies based on whole genome sequencing are now becoming feasible. It is still unclear, however, how much more we could gain from whole genome sequencing compared to exome sequencing, which has been widely used to study a variety of diseases. In this project, we performed a comparison between whole(More)
In this paper, we present demand-side energy management under real-time demand-response pricing as a task scheduling problem which is NP-hard. Using minmax as the objective, we show that the schedule produced by our minMax scheduling algorithm has a number of salient advantages: significant peak-shaving, cost reduction, and risk-aversion for the consumers.(More)
STUDY DESIGN This is a retrospective study. PURPOSE We wanted to investigate the clinical relevance of the lumbar high intensity zone (HIZ) on magnetic resonance imaging (MRI) and the relationship of trauma history to internal disc disruption (IDD). OVERVIEW OF LITERATURE HIZs on lumbar spine (L-spine) MRI have been suggested as a reliable marker of IDD(More)
Public cloud storage has recently surged in popularity. However, cloud storage providers (CSPs) today offer fairly rigid services, which cannot be customized to meet individual users' needs. We propose a distributed, client-defined architecture that integrates multiple autonomous CSPs into one unified cloud and allows individual clients to specify their(More)
Recently, several mobile services are changing to cloud-based mobile services with richer communications and higher flexibility. We present a new mobile cloud infrastructure that combines mobile devices and cloud services. This new infrastructure provides virtual mobile instances through cloud computing. To commercialize new services with this(More)