Jae Yong Shin

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Cyclooxygenase-2 (COX-2) is an enzyme induced in response to multiple mitogenic and inflammatory stimuli, including UV light. UV-induced COX-2 expression induces production of prostaglandin E2 (PGE2) in keratinocytes, which mediates inflammation and cell proliferation. Until recently, studies regarding COX-2 and PGE2 in the skin have focused on(More)
BACKGROUND Fractional microneedle radiofrequency (FMR) devices deliver energy to the deep dermis through insulated microneedles without destroying the epidermis. These FMR devices have been shown to be effective for the treatment of wrinkles, acne scars and large pores. In this study it was postulated that FMR energy could specifically affect the sweat(More)
BACKGROUND Segmental vitiligo (SV), which frequently accompanies poliosis, indicating a poor prognosis that is likely resistant to treatments. OBJECTIVES In this study, we performed a retrospective analysis to evaluate the treatment response to 308 nm excimer laser in SV patients. METHODS A retrospective chart and photographic review was performed on 80(More)
Standard principal-agent theory is generally based on gross performance measures (i.e., before compensation expense), yet boards in practice also determine incentive compensation using net performance measures (i.e., after deducting compensation expense). In a multi-principal, multi-agent model where relative performance evaluation arises endogenously, we(More)
• The authors have no financial conflicts of interest. which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 57-year-old woman presented with multiple, asymptomatic, variable-sized, erythematous nodules that had been present for the previous two months on both inferior(More)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Dear Editor: Focal acantholytic dyskeratosis (FAD)(More)
BACKGROUND Cytosolic NADP(+)-dependent ICDH (IDPc) has an antioxidant effect as a supplier of NADPH to the cytosol, which is needed for the production of glutathione. OBJECTIVE To evaluate the expression of IDPc in melanocytes and to elucidate its role as an antioxidant. METHODS The knock-down of IDPc expression in immortalized mouse melanocyte cell(More)
We examine the effect of missing quarterly earnings benchmarks on Chief Financial Officer (CFO) turnover and compensation. We consider two well-known earnings benchmarks: 1) consensus analyst earnings forecast, and 2) earnings for the same quarter of the prior year. Our results are consistent with significant bonus and career consequences to CFOs of failure(More)
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