Jae Wook Lee

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Impairment of the circadian clock has been associated with numerous disorders, including metabolic disease. Although small molecules that modulate clock function might offer therapeutic approaches to such diseases, only a few compounds have been identified that selectively target core clock proteins. From an unbiased cell-based circadian phenotypic screen,(More)
The circadian clock controls daily oscillations of gene expression at the cellular level. We report the development of a high-throughput circadian functional assay system that consists of luminescent reporter cells, screening automation, and a data analysis pipeline. We applied this system to further dissect the molecular mechanisms underlying the mammalian(More)
Novel slot-shaped defected ground structures (DGSs) on the microstrip line are presented to provide a band-rejection property with an improved Q factor. Two different geometries (U-slot and V-slot) are investigated. U-slot and V-slot DGSs have simple shapes compared to the conventional DGSs, however, they provide more steep rejection characteristics. The Q(More)
The circadian clock underlies daily rhythms of diverse physiological processes, and alterations in clock function have been linked to numerous pathologies. To apply chemical biology methods to modulate and dissect the clock mechanism with new chemical probes, we performed a circadian screen of ,120,000 uncharacterized compounds on human cells containing a(More)
Many living organisms including bacteria, fungi, plants, and animals have observable, genetically determined biological rhythms. The rhythm affects many aspects of mammalian behavior and physiology including sleep, physical activity, alertness, hormone levels, body temperature, immune function, and digestive activity. These circadian rhythms are controlled(More)
BACKGROUND Adipose-derived stem cells (ASCs) have positive effects in the wound healing process. OBJECTIVE To clarify whether ASCs positively mitigate scar formation in the wound remodeling process. MATERIALS AND METHODS Full-thickness skin defects were created on the dorsal skin of Yorkshire pigs. After the defects were transformed into early scars,(More)
Pharmacological factors are needed to prevent bone loss that occurs with increasing age. The chemical compounds that act on bone metabolism in herbal medicines, however, are poorly understood. Effects of traditional Korean medicine, Drynariae Rhizoma [Drynaria fortunei (kunze) J. Sm] extract (DR), on the osteoblastic proliferation and differentiation were(More)
The supramolecular chemistry of cucurbituril, a synthetic receptor, is fascinating because of the remarkable guest binding behavior of the host. Studies in the field, however, have met with limitations, since the only species known was the hexameric macrocyclic compound, cucurbit[6]uril. Recently we synthesized its homologues, cucurbit[n]uril (n = 5, 7, 8),(More)
Haemophilus influenzae frequently colonizes the nasopharynx of children and adults, which can lead to a variety of infections. We investigated H. influenzae carriage in the nasopharynx of 360 children, in terms of (1) the prevalence of strains with decreased susceptibility, and (2) the presence of amino acid substitutions in PBP3. One hundred twenty-three(More)
B-cell activating factor (BAFF) plays a role for the maturation and the maintenance of B cells. Lipopolysaccharide (LPS) activates toll-like receptor 4 (TLR4)-dependent signal transduction, which resulted in BAFF expression through nuclear factor kappa B (NF-κB) activation. Here, we investigated whether BAFF expression could be regulated by p65(More)