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The Raw microprocessor consumes 122 million transistors, executes 16 different load, store, integer or floating point instructions every cycle, controls 25 GB/s of I/O bandwidth, and has 2 MB of on-chip, distributed L1 SRAM memory, providing on-chip memory bandwidth of 43 GB/s. Is this the latest billion-dollar 3,000 man-year processor effort? In fact, Raw(More)
Modern cryptographic protocols are based on the premise that only authorized participants can obtain secret keys and access to information systems. However, various kinds of tampering methods have been devised to extract secret keys from widely fielded conditional access systems such as smartcards and ATMs. As a solution, Arbiter-based Physical Unclonable(More)
We present a simple architectural mechanism called dynamic information flow tracking that can significantly improve the security of computing systems with negligible performance overhead. Dynamic information flow tracking protects programs against malicious software attacks by identifying spurious information flows from untrusted I/O and restricting the(More)
This paper describes a technique that exploits the statistical delay variations of wires and transistors across ICs to build a secret key unique to each IC. To explore its feasibility, we fabricated a candidate circuit to generate a response based on its delay characteristics. We show that there exists enough delay variation across ICs implementing the(More)
BACKGROUND Alzheimer's disease (AD) is characterized by extensive loss of neurons in the brain of AD patients. Intracellular accumulation of beta-amyloid peptide (Abeta) has also shown to occur in AD. Neuro-inflammation has been known to play a role in the pathogenesis of AD. METHODS In this study, we investigated neuro-inflammation and amyloidogenesis(More)
Beta-amyloid peptide (Abeta) is considered responsible for the pathogenesis of Alzheimer's disease (AD). Several lines of evidence support that Abeta-induced cytotoxicity is mediated through the generation of reactive oxygen species (ROS). Thus, agents that scavenge ROS level may usefully impede the development or progress of AD. Green tea extract has been(More)
DRAM has been a de facto standard for main memory, and advances in process technology have led to a rapid increase in its capacity and bandwidth. In contrast, its random access latency has remained relatively stagnant, as it is still around 100 CPU clock cycles. Modern computer systems rely on caches or other latency tolerance techniques to lower the(More)
Neuroinflammation has been known to play a role in the pathogenesis of AD. Our previous study showed that lipopolysaccharide (LPS) induced memory impairment through the accumulation of Abeta via the increase of beta- and gamma-secretase. In this study, we investigated the possible preventive effect of (-)-epigallocatechin-3-gallate (EGCG) on memory(More)
Higher transistor counts, lower voltage levels, and reduced noise margin increase the susceptibility of multicore processors to transient faults. Redundant hardware modules can detect such errors, but software transient fault detection techniques are more appealing for their low cost and flexibility. Recent software proposals double register pressure or(More)
Emerging many-core chip multiprocessors will integrate dozens of small processing cores with an on-chip interconnect consisting of point-to-point links. The interconnect enables the processing cores to not only communicate, but to share common resources such as main memory resources and I/O controllers. In this work, we propose an arbitration scheme to(More)