Jae-Suk Choi

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Reductions in neurotrophic factors are implicated in synaptic dysfunction in the central nervous system, but exogenous neurotrophic factors with potential effects on neuritic regeneration and synaptic reconstruction could offer therapeutic and preventive strategies for treating memory-related neurological disorders. In an earlier effort to identify natural(More)
This study evaluated the effects of Polycan, a β-glucan produced by Aureobasidium pullulans SM-2001, on calcium (Ca) bioavailability in an ovariectomy (OVX) model and a thyroparathyroidectomy (TPTX) model of osteoporosis in the SD rat. Polycan (62.5, 125, and 250 mg/kg body weight) was administered daily with an oral gavage for 4 weeks in both the OVX group(More)
Constipation is a common problem in males and females. The aim of the present study was to evaluate the laxative effects of fermented rice extract (FRe) on rats with loperamide-induced constipation. FRe (100, 200 and 300 mg/kg) was administered orally once per day for six days following 1 h loperamide treatment. The laxative effects of FRe were compared(More)
The aim of the present study was to investigate the optimum composition of Polycan (β-glucan complex) and calcium lactate-gluconate (CaLG) that exhibited the most beneficial effects in ovariectomy (OVX)‑induced osteoporotic rats. Polycan and CaLG single formulas (100 mg/kg each), and three doses (50, 100 and 200 mg/kg) of three mixed formulas [polycan:CaLG(More)
We found that the edible green seaweed Enteromorpha linza displayed potent antimicrobial activity against Prevotella intermedia and Porphyromonas gingivalis. To elucidate the active component of E. linza, isolation procedures were performed. The main active compound was isolated by polarity fractionation, Sephadex LH-20 gel chromatography, and reverse-phase(More)
The edible red alga Porphyra yezoensis is among the most popular marine algae and is of economic and medicinal importance. In the present study, the neurotrophic and neuroprotective activities of the ethanol extract of P. yezoensis (PYE) were investigated in primary cultures of hippocampal neurons. Results revealed that PYE significantly increased neurite(More)
Sargassum fulvellum (Turner) C. Agardh is an edible brown macroalgae having pharmacological importance. In previous reports, we described the screening of marine algae for their neuritogenic activity in developing hippocampal neurons and found that ethanol extract of S. fulvellum (SFE) possesses promising neurite-outgrowth-promoting activity. In this study,(More)
The present study was performed to evaluate the laxative effects of fermented rice extract (FRe) in normal rats. FRe was orally administered at doses of 100, 200, and 300 mg/kg once per day for 15 days, and the changes in fecal parameters (fecal pellet numbers, weights, and water contents), gastrointestinal transit ratio, fecal mucus contents, colonic(More)
The aim of this study was to evaluate the toxicity of rice bran supercritical CO2 extract (RB-SCE) in vitro and in vivo. A cytotoxicity assay revealed no inhibitory effects on cell viability in a mouse leukemic monocyte macrophage cell line (RAW 264.7) after 24-h incubation with 0.16 or 0.32 μg/mL of RB-SCE. RB-SCE was administered to male and female(More)
The development of a simple and effective long-term storage protocol for harvested fresh Undaria pinnatifida is required to increase the market for U. pinnatifida products. We investigated the quality of U. pinnatifida after the application of various freezing and thawing methods to establish an optimum storage protocol. Four freezing temperatures (−40,(More)