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BACKGROUND Sensing and responding to environmental changes is a central aspect of cell division regulation. Mycobacterium tuberculosis contains eleven Ser/Thr kinases, two of which, PknA and PknB, are key signaling molecules that regulate cell division/morphology. One substrate of these kinases is Wag31, and we previously showed that partial depletion of(More)
PURPOSE A subset of patients with adenocarcinoma of the lung who had never smoked cigarettes showed excellent tumor responses to gefitinib therapy. To evaluate the efficacy of gefitinib as a first-line therapy in this subgroup of patients, we conducted a phase II study. EXPERIMENTAL DESIGN Eligible patients had no smoking history, stage IIIB or IV(More)
Plasmablastic lymphoma (PBL) is a recently identified entity that is considered to be a type of diffuse large B-cell lymphoma with a unique immunophenotype and a predilection for the oral cavity of patients with the human immunodeficiency virus (HIV). Although its clinical features may help in the differential diagnosis, an extraoral location in a patient(More)
OBJECTIVE The effectiveness of capecitabine, an oral fluoropyrimidine carbamate, is well documented in previously untreated metastatic colorectal cancer patients (overall response rate: 25%). However, its efficacy in patients with metastatic colorectal cancer refractory to 5-fluorouracil/leucovorin (5-FU/LV) has not been determined. This study was performed(More)
New 60GHz OOK modulator and demodulator are presented in this paper. A proposed 60GHz OOK modulator is designed in a 90nm CMOS process by current reuse and dual modulation technique and has 28.5dB high on/off isolation, and 10dB gain at 60GHz with 14.4mW at on-state of an OOK digital signal. It can process OOK digital signals up to 2Gbps. Measured OP1dB is(More)
PURPOSE The novel heat shock protein tumor necrosis factor receptor-associated protein 1 (TRAP1) is associated with multidrug resistance in colorectal cancer (CRC) cells in vitro. Excision repair cross-complementation group 1 (ERCC1) expression levels in tumor tissues also predict clinical outcomes in metastatic CRC patients receiving combination(More)
A 60GHz transceiver system with low-power CMOS OOK modulator and demodulator is presented in this paper. The 60 GHz modulator is designed in a 90-nm CMOS process by current reuse and consumes 14.4-mW dc power at the ON-state. A data rate of up to 2 Gb/s has been measured. The 60GHz OOK demodulator is designed in a 130nm CMOS process. The demodulator(More)
Carbapenems (imipenem, meropenem, biapenem, ertapenem, and doripenem) are β-lactam antimicrobial agents. Because carbapenems have the broadest spectra among all β-lactams and are primarily used to treat infections by multi-resistant Gram-negative bacteria, the emergence and spread of carbapenemases became a major public health concern. Carbapenemases are(More)
PURPOSE The purpose of this study was to compare topographical maps using a novel EEG-based brain mapping system with fMRI in normal and children with cerebral palsy (CP) during a grasping motor task. METHOD A normal child (mean ± SD = 13 ± 0 yrs) and four children with CP (mean ± SD = 10.25 ± 2.86 yrs) were recruited from a local community school and(More)