Learn More
BACKGROUND Sensing and responding to environmental changes is a central aspect of cell division regulation. Mycobacterium tuberculosis contains eleven Ser/Thr kinases, two of which, PknA and PknB, are key signaling molecules that regulate cell division/morphology. One substrate of these kinases is Wag31, and we previously showed that partial depletion of(More)
PURPOSE A subset of patients with adenocarcinoma of the lung who had never smoked cigarettes showed excellent tumor responses to gefitinib therapy. To evaluate the efficacy of gefitinib as a first-line therapy in this subgroup of patients, we conducted a phase II study. EXPERIMENTAL DESIGN Eligible patients had no smoking history, stage IIIB or IV(More)
Plasmablastic lymphoma (PBL) is a recently identified entity that is considered to be a type of diffuse large B-cell lymphoma with a unique immunophenotype and a predilection for the oral cavity of patients with the human immunodeficiency virus (HIV). Although its clinical features may help in the differential diagnosis, an extraoral location in a patient(More)
New 60GHz OOK modulator and demodulator are presented in this paper. A proposed 60GHz OOK modulator is designed in a 90nm CMOS process by current reuse and dual modulation technique and has 28.5dB high on/off isolation, and 10dB gain at 60GHz with 14.4mW at on-state of an OOK digital signal. It can process OOK digital signals up to 2Gbps. Measured OP1dB is(More)
PURPOSE The novel heat shock protein tumor necrosis factor receptor-associated protein 1 (TRAP1) is associated with multidrug resistance in colorectal cancer (CRC) cells in vitro. Excision repair cross-complementation group 1 (ERCC1) expression levels in tumor tissues also predict clinical outcomes in metastatic CRC patients receiving combination(More)
A 60GHz transceiver system with low-power CMOS OOK modulator and demodulator is presented in this paper. The 60 GHz modulator is designed in a 90-nm CMOS process by current reuse and consumes 14.4-mW dc power at the ON-state. A data rate of up to 2 Gb/s has been measured. The 60GHz OOK demodulator is designed in a 130nm CMOS process. The demodulator(More)
Carbapenems (imipenem, meropenem, biapenem, ertapenem, and doripenem) are β-lactam antimicrobial agents. Because carbapenems have the broadest spectra among all β-lactams and are primarily used to treat infections by multi-resistant Gram-negative bacteria, the emergence and spread of carbapenemases became a major public health concern. Carbapenemases are(More)
PURPOSE The purpose of this study was to compare topographical maps using a novel EEG-based brain mapping system with fMRI in normal and children with cerebral palsy (CP) during a grasping motor task. METHOD A normal child (mean ± SD = 13 ± 0 yrs) and four children with CP (mean ± SD = 10.25 ± 2.86 yrs) were recruited from a local community school and(More)
Kummell's disease is a spinal disorder characterized by delayed post-traumatic collapse of a vertebral body with avascular necrosis. Although definitive treatment for Kummell's disease has not been established, it has been reported that percutaneous vertebroplasty or kyphoplasty has shown good results. However, these procedures are not recommended for(More)