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RNA-protein interactions are vitally important in a wide range of biological processes, including regulation of gene expression, protein synthesis, and replication and assembly of many viruses. We have developed a computational tool for predicting which amino acids of an RNA binding protein participate in RNA-protein interactions, using only the protein(More)
Understanding interactions between proteins and RNA is key to deciphering the mechanisms of many important biological processes. Here we describe RNABindR, a web-based server that identifies and displays RNA-binding residues in known protein-RNA complexes and predicts RNA-binding residues in proteins of unknown structure. RNABindR uses a distance cutoff to(More)
Protein-protein and protein nucleic acid interactions are vitally important for a wide range of biological processes, including regulation of gene expression, protein synthesis, and replication and assembly of many viruses. We have developed machine learning approaches for predicting which amino acids of a protein participate in its interactions with other(More)
A cis-acting RNA regulatory element, the Rev-responsive element (RRE), has essential roles in replication of lentiviruses, including human immunodeficiency virus (HIV-1) and equine infection anemia virus (EIAV). The RRE binds the viral trans-acting regulatory protein, Rev, to mediate nucleocytoplasmic transport of incompletely spliced mRNAs encoding viral(More)
This paper concerns an efficient network joining method for mobile nodes in USNs (ubiquitous sensor networks) based on the IEEE 802.15.4 standard. The MSBS (mobile sensor beacon setup) method is proposed for performance enhancements of the mobile nodes using the depth, traffic, and RSSI (received signal strength indication) information. The MSBS method can(More)
RNA molecules play diverse functional and structural roles in cells: they function as messengers for transferring genetic information from DNA to proteins, as the primary genetic material in many viruses, as enzymes important for protein synthesis and RNA processing, and as essential and ubiquitous regulators of gene expression in living organisms. All of(More)
Telomerase is a ribonucleoprotein enzyme that adds telomeric DNA repeat sequences to the ends of linear chromosomes. The enzyme plays pivotal roles in cellular senescence and aging, and because it provides a telomere maintenance mechanism for approximately 90% of human cancers, it is a promising target for cancer therapy. Despite its importance, a(More)