Jae-Chun Ryu

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Iodothyronine deiodinase types I, II, and III (D1, D2, and D3, respectively), which constitute a family of selenoenzymes, activate and inactivate thyroid hormones through the removal of specific iodine moieties from thyroxine and its derivatives. These enzymes are important in the biological effects mediated by thyroid hormones. The expression of activating(More)
The vast quantities of information on toxicogenomics such as genome sequence, genotype, gene expression, phenotype, disease information, etc. are reflected in scientific literature. However, these various and heterogeneous data has to be reconstructed by proper data model to enhance our understanding. This study suggests a semantic modeling to organize(More)
Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is carcinogenic to humans. Although the environmental distribution and metabolism of BaP have been reported and many researchers are performing risk-assessment and toxicological studies of BaP by means of physical and chemical measurements, only a few studies have examined the expression(More)
Although hexanal is considered to be a major air pollutant the correlation between hexanal and health risk is largely unknown. Identifying aldehyde toxicity in eukaryotic cells will be useful for preventing and treating environmental diseases and disorders. However, it is important to note that previous microRNA (miRNA) studies of hexanal have not yet(More)
In this paper, we examine the model for a chemical exposure decision support algorithm. Our purpose is to suggest the model frame to describe possibility of exposure with low-dose VOC chemicals for long time under normal circumstances at working place. Forensic rhetoric terms, non-exclusion exposure suspicion (NES) and exclusion exposure suspicion (EES),(More)
Butanal is a lower-molecular-weight saturated aliphatic aldehyde (LSAA) that is known as one of the important causes of indoor pollution. Although a few studies have been reported, the toxicity of butanal and its underlying mechanisms remain unclear. This study focused on toxicity of butanal with microarray analysis relationships of gene expression patterns(More)
We have shown that aldehydes impact gene expression profiles of bronchial airway associated with pulmonary toxicity. In this study, we aimed to determine whether microRNA (miRNA) plays a role in regulating the airway gene expression response to aldehyde exposure. We analyzed whole genome miRNA and mRNA expression profiles upon nonanal exposure of human(More)
Dibutyl phthalates (DBP) are widely used as plasticizers to soften and increase the flexibility of polyvinyl chloride plastics, although they can leach into the surrounding environment. Many studies have reported that changes in thyroid function are linked to a variety of chemicals in the environment. Although the mechanism is not known, DBP decreases T3(More)
Toxicology studies assessing the risk of environmental toxicants in humans frequently use in vitro systems in combination with transcriptomics to characterize toxic responses. Thus far, changes have mostly been investigated at the mRNA level. Recently, microRNAs (miRNAs) have attracted attention because they are powerful negative regulators of mRNA levels(More)
Low-molecular weight saturated aliphatic aldehydes (LSAAs), which include propanal, butanal, pentanal, hexanal, octanal, nonanal and heptanal, are volatile organic compounds (VOCs). They are ubiquitous in the environment of our daily life. Although LSAAs are harmful, with mutagenic and carcinogenic effects, the mechanisms underlying the toxicity of volatile(More)