Jacques Renault

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The effects of several N-sulfonyl-polyamines, including N1-dansyl-spermine (N1-DnsSpm) and N1-(n-octanesulfonyl)-spermine (N1-OsSpm), were studied at recombinant N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus laevis oocytes. N1-DnsSpm and N1-OsSpm inhibited NMDA receptors and were approximately 1000-fold more potent than spermine in oocytes(More)
Given a semigroup of surjective local homeomorphisms on a compact space X we consider the corresponding semigroup of *-endomorphisms on C(X) and discuss the possibility of extending it to an interaction group, a concept recently introduced by the first named author. We may also define a transformation groupoid whose C*-algebra turns out to be isomorphic to(More)
NOTICE: This is the author's version of a work that was accepted for publication in Brain Research following peer review. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it(More)
The potential polyamine antagonist action of N1-dansyl-spermine (a potent NMDA antagonist) was assessed in two in vivo mouse models of polyamine action. Co-administration of N1-dansyl-spermine (2-10 microg, i.c.v.) with spermine (100 microg, i.c.v.) resulted in a dose-dependent antagonism of the spermine-induced CNS excitation (body tremor and fatal tonic(More)
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