Jacques M G W Wouters

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The clinical and laboratory features, treatment, prognosis, complications and disability of 45 patients with adult-onset Still's disease were studied. Sixty per cent of the patients were female. Median age at onset was 25 years and median observation period after onset was 41 months. For 28 patients detailed data were available of the first month of(More)
Various cytokines and inflammatory mediators are known to be involved in the pathogenesis of rheumatoid arthritis (RA). We hypothesized that polymorphisms in selected inflammatory response and tissue repair genes contribute to the susceptibility to and severity of RA. Polymorphisms in TNFA, IL1B, IL4, IL6, IL8, IL10, PAI1, NOS2a, C1INH, PARP, TLR2 and TLR4(More)
Several micro-organisms, especially viruses, have been associated with juvenile and adult onset Still's disease. In the present study a search for probable triggering viral infections in five consecutive patients with early, active adult onset Still's disease has been made. In one patient echovirus 7 was identified as a probable triggering agent. Evidence(More)
OBJECTIVE To examine the relationship of fatigue in people with rheumatoid arthritis (RA) with self-efficacy, positive and problematic aspects of social support, and demographic and disease-related variables. METHOD Out-patients with at least 5 yr RA were studied. Fatigue was measured with a visual analogue scale. Other variables included were: positive(More)
Disease course and HLA antigens were determined in 29 patients with definite and 13 patients with probable adult-onset Still's disease (AOSD). Twenty-six patients had persistent disease with continuous disease activity for at least 1 year. Radiographic examination revealed evidence of joint destruction in 26 patients. In 15 patients, at least 1 root joint(More)
B. Aharmim,6 S. N. Ahmed,14 A. E. Anthony,17,* N. Barros,8 E. W. Beier,13 A. Bellerive,4 B. Beltran,1 M. Bergevin,5,7 S. D. Biller,12 K. Boudjemline,4 M. G. Boulay,14 T. H. Burritt,19 B. Cai,14 Y. D. Chan,7 D. Chauhan,6 M. Chen,14 B. T. Cleveland,12 G. A. Cox,19 X. Dai,4,12,14 H. Deng,13 J. Detwiler,7 M. DiMarco,14 P. J. Doe,19 G. Doucas,12 P.-L. Drouin,4(More)
An array of Neutral-Current Detectors (NCDs) has been built in order to make a unique measurement of the total active flux of solar neutrinos in the Sudbury Neutrino Observatory (SNO). Data in the third phase of the SNO experiment were collected between November 2004 and November 2006, after the NCD array was added to improve the neutral-current sensitivity(More)
B. Aharmim, S. N. Ahmed, J. F. Amsbaugh, A. E. Anthony, J. Banar, N. Barros, E.W. Beier, A. Bellerive, B. Beltran, M. Bergevin, S. D. Biller, K. Boudjemline, M.G. Boulay, T. J. Bowles, M. C. Browne, T. V. Bullard, T. H. Burritt, B. Cai, Y.D. Chan, D. Chauhan, M. Chen, B. T. Cleveland, G.A. Cox-Mobrand, C. A. Currat, X. Dai, H. Deng, J. Detwiler, M. DiMarco,(More)
Two patients with the first symptoms of adult onset Still's disease in their 7th decade are reported. In both cases their advanced age was a main reason for a prolonged delay in diagnosis. Besides the characteristic fever pattern, rash and arthritis, our patients showed other typical features of Still's disease such as splenomegaly, pleuritis, pneumonitis,(More)
A 34-year-old man with adult-onset Still's disease developed a striking hypercalcaemia during a rapidly destructive polyarthritis with extensive osteoporosis. The hypercalcaemia seemed to be primarily caused by inflammation-induced bone resorption. On prednisone the polyarthritis went into remission and the plasma calcium levels became normal. Other(More)