Jacques Donnez

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BACKGROUND The lifesaving treatment endured by cancer patients leads, in many women, to early menopause and subsequent infertility. In clinical situations for which chemotherapy needs to be started, ovarian tissue cryopreservation looks to be a promising option to restore fertility. In 1997, biopsy samples of ovarian cortex were taken from a woman with(More)
Aggressive chemotherapy/radiotherapy and bone marrow transplantation can cure >90% of girls and young women affected by disorders requiring such treatment. However, the ovaries are very sensitive to cytotoxic drugs, especially to alkylating agents. Several options are currently available to preserve fertility in cancer patients. The present review reports(More)
OBJECTIVE To review the histogenesis of peritoneal, ovarian, and rectovaginal endometriotic lesions. DESIGN The comparison of morphologic, morphometric, and histochemical data observed in each type of lesion. SETTING A university hospital department of gynecology. PATIENT(S) Patients complaining of infertility or pelvic pain with laparoscopically(More)
The review covers current options for ovarian tissue cryopreservation and transplantation and provides a systematic review of the existing literature from the last 10 years, taking into account all previously published reviews on the subject. The different cryopreservation options available for fertility preservation in cancer patients are embryo(More)
Angiogenesis is likely to be involved in the pathogenesis of endometriosis. According to the transplantation theory, when the exfoliated endometrium is attached to the peritoneal layer, the establishment of a new blood supply is essential for the survival of the endometrial implant and development of endometriosis. From the known angiogenic factors,(More)
INTRODUCTION. Premature ovarian failure (POF) can occur naturally at an early age or be due to iatrogenic agents. Indeed, ovaries are very sensitive to cytotoxic treatment, especially to radiation and alkylating agents. METHODS. Several options are currently available to preserve fertility in cancer patients and allow them to conceive when they have(More)
OBJECTIVE To test the feasibility of freezing intact human ovary using a passive cooling device. DESIGN Prospective experimental study. SETTING Academic research unit of the department of gynecology in a university hospital. PATIENT(S) Ovaries were obtained from three women who were between 29 and 36 years of age. INTERVENTION(S) Ovarian perfusion(More)
In women, ∼10% of cancers occur in those <45 years old. Chemotherapy, radiotherapy and bone marrow transplantation can cure >90% of girls and young women with diseases that require such treatments. However, these treatments can result in premature ovarian failure, depending on the follicular reserve, the age of the patient and the type and dose of drugs(More)
OBJECTIVE To evaluate the implantation of menstrual endometrium and the early stages of evolution of endometriotic lesions. DESIGN Experimental prospective study. SETTING An academic research environment. ANIMALS Ten nude mice. INTERVENTION(S) A minilaparotomy was performed to place fresh human menstrual endometrial samples in the peritoneal cavity.(More)
OBJECTIVE The aim of this study was to evaluate the complication rate after laparoscopic total hysterectomy and laparoscopic subtotal hysterectomy (LASH) in case of benign disease. DESIGN All complications were prospectively recorded at the time of surgery and analysed retrospectively. SETTING University hospital. POPULATION Among 4505 hysterectomies(More)