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p73 (ref. 1) has high homology with the tumour suppressor p53 (refs 2-4), as well as with p63, a gene implicated in the maintenance of epithelial stem cells. Despite the localization of the p73 gene to chromosome 1p36.3, a region of frequent aberration in a wide range of human cancers, and the ability of p73 to transactivate p53 target genes, it is unclear(More)
Neuropilin 2 (NRP2) is a receptor for the vascular endothelial growth factor (VEGF) and the semaphorin (SEMA) families, 2 unrelated ligand families involved in angiogenesis and neuronal guidance. NRP2 specifically binds VEGF-A and VEGF-C, although the biological relevance of these interactions in human endothelial cells is poorly understood. In this study,(More)
SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively. SAR131675 dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD, with an IC(50) of(More)
Myeloid derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) represent prominent components in cancer progression. We previously showed that inhibition of the VEGFR-3 pathway by SAR131675 leads to reduction of TAM infiltration and tumor growth. Here, we found that treatment with SAR131675 prevents the accumulation of immunosuppressive(More)
Introduction Members of the vascular endothelial cell growth factor (VEGF) family are the most important mediators of angiogenesis and lymphangiogenesis. 1 These factors recognize at least 2 cell surface receptor families, the tyrosine kinase receptors (VEGFR) and the neuropilin (NRP) receptors. Three VEGFRs have been identified: VEGFR-1 (Flt-1), VEGFR-2(More)
Running title: SAR131675 a potent and selective VEGFR-3 inhibitor Precis : SAR131675, a highly active and specific VEGFR-3 inhibitor, reduces lymphangiogenesis and angiogenesis and also tumor associated macrophages infiltration and as consequences, it reduces tumor growth and metastasis Keywords: Angiogenesis / lymphangiogenesis / tyrosine kinase / VEGF-R3(More)
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