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p73 (ref. 1) has high homology with the tumour suppressor p53 (refs 2-4), as well as with p63, a gene implicated in the maintenance of epithelial stem cells. Despite the localization of the p73 gene to chromosome 1p36.3, a region of frequent aberration in a wide range of human cancers, and the ability of p73 to transactivate p53 target genes, it is unclear(More)
Neuropilin 2 (NRP2) is a receptor for the vascular endothelial growth factor (VEGF) and the semaphorin (SEMA) families, 2 unrelated ligand families involved in angiogenesis and neuronal guidance. NRP2 specifically binds VEGF-A and VEGF-C, although the biological relevance of these interactions in human endothelial cells is poorly understood. In this study,(More)
Myeloid derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) represent prominent components in cancer progression. We previously showed that inhibition of the VEGFR-3 pathway by SAR131675 leads to reduction of TAM infiltration and tumor growth. Here, we found that treatment with SAR131675 prevents the accumulation of immunosuppressive(More)
SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively. SAR131675 dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD, with an IC(50) of(More)
Running title: SAR131675 a potent and selective VEGFR-3 inhibitor Precis : SAR131675, a highly active and specific VEGFR-3 inhibitor, reduces lymphangiogenesis and angiogenesis and also tumor associated macrophages infiltration and as consequences, it reduces tumor growth and metastasis Keywords: Angiogenesis / lymphangiogenesis / tyrosine kinase / VEGF-R3(More)
Introduction Members of the vascular endothelial cell growth factor (VEGF) family are the most important mediators of angiogenesis and lymphangiogenesis. 1 These factors recognize at least 2 cell surface receptor families, the tyrosine kinase receptors (VEGFR) and the neuropilin (NRP) receptors. Three VEGFRs have been identified: VEGFR-1 (Flt-1), VEGFR-2(More)
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