Jacquelyn R Clarkson

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Chronic effects of aflatoxins may be reducing the efficiency of swine production unit by decreasing the immune response leading to increased susceptibility to disease and increased mortality, and decreasing resistance to stress. The individual pig's response to aflatoxin is affected by many factors, but age is especially important with the younger pig much(More)
This paper presents a critical review of the information pertaining to the potential carcinogenicity of 1,4-dioxane. The primary target organs for cancer via the oral route are the liver and the nasal cavity, however, the relevance of nasal cavity tumors to human exposures has been questioned. Liver tumors were accompanied by degenerative changes and appear(More)
1,4-Dioxane (CAS No. 123-91-1) is used primarily as a solvent or as a solvent stabilizer. It can cause lung, liver, and kidney damage at sufficiently high exposure levels. Two physiologically based pharmacokinetic (PBPK) models of 1,4-dioxane and its major metabolite, hydroxyethoxyacetic acid (HEAA), were published in 1990. These models have uncertainties(More)
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