Jacquelyn A. Reed

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Innate immunity plays an important role in pulmonary host defense against Pneumocystis carinii, an important pathogen in individuals with impaired cell-mediated immunity. We investigated the role of GM-CSF in host defense in a model of P. carinii pneumonia induced by intratracheal inoculation of CD4-depleted mice. Lung GM-CSF levels increased progressively(More)
Rats prone to develop diet-induced obesity (DIO) have reduced central sensitivity to many metabolic and hormonal signals involved in energy homeostasis. High-fat diets produce similar defects in diet-resistant (DR) rats. To test the hypothesis that genotype and diet exposure would similarly affect central insulin signaling, we assessed the anorectic effects(More)
Signal transducers and activators of transcription (STATs) are critical components of cytokine signaling pathways. STAT5A and STAT5B (STAT5), the most promiscuous members of this family, are highly expressed in specific populations of hypothalamic neurons in regions known to mediate the actions of cytokines in the regulation of energy balance. To test the(More)
BACKGROUND Melanocytic nevi typically show a morphologic sequence of maturation from epithelioid "type A" cells to fusiform, Schwann cell-like "type C" cells with dermal descent. Nevi may also produce Wagner-Meissner-like structures (nevic corpuscles). Previous studies have shown that this maturation of intradermal nevi recapitulates intermediate stages in(More)
1. The effects of cocaine on locomotor activity and striatal dopaminergic receptors and dopamine turnover were studied in rat pups exposed to cocaine (30 mg/kg/day) throughout the entire gestational period. 2. Prenatal exposure to cocaine did not alter the motor coordination or spontaneous locomotor activity in the offspring. 3. No change in the(More)
1. The acute and chronic effects of nicotine (1.5 mg/kg/day) on the striatal and mesolimbic GABAergic systems were examined in the rat. 2. Despite altering the striatal DAergic activity, neither acute nor chronic administration of nicotine significantly affected the GABAergic system. 3. The nicotine treatment did not alter the ability of muscimol to inhibit(More)
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