Jacqueline van der Wees

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COUP-TFs (Chicken Ovalbumin Upstream Promoter Transcription Factors) have been proposed to be negative regulators of retinoid receptor-mediated transcriptional activation. In a previous paper we reported the cloning of a Xenopus (x) COUP-TF (Matharu, P.J. and Sweeney, G.E. (1992) Biochim. Biophys. Acta 1129, 331-334). Here we describe the cloning of a(More)
There are many indications that active retinoids are regulatory signals during vertebrate embryogenesis. Treating vertebrate embryos with retinoids can cause teratogenic defects, including specific derangements of the main body axis. Other data show that early vertebrate embryos contain physiologically relevant concentrations of active retinoids and express(More)
This workshop was the third of a series, following two previous workshops in Vienna in August 1996 and in Copenhagen in May 1997. Its theme was the practical use and integration of machine translation and computer-based translation tools in the workflow of a variety of organisations. Preface John Hutchins 5 Workflow using linguistic technology at the(More)
Eine chronisch persistierende Parvovirus-B19-Myokarditis ist im Kleinkindalter bisher nicht beschrieben. Der Verlauf bei einem 17 Monate alten Jungen, der mit einer dekompensierten dilatativen Kardiomyopathie aufgenommen wurde, wird geschildert. Voraussetzung für die Diagnose war die Endomyokardbiopsie im Rahmen einer Herzkatheteruntersuchung. Diese sollte(More)
The aim of this study was to report the efficacy of adding chlorhexidine to the protocol for decontamination of human donor globes prior to excision of corneo-scleral rims for future keratoplasty procedures. In 2005, chlorhexidine was introduced by our eye bank as an additional step in the protocol for decontaminating human donor globes. After 5 years, we(More)
Anterior donor grafts (including scleral rim, without Descemet membrane) increase in thickness and become hazy upon storage in organ culture (OC) medium. Transfer of these grafts to standard dehydration media just before transplantation does not reduce their thickness to normal. Therefore, we assessed the efficacy of different media enriched with(More)
Mortality and long-term neurologic sequelae are still frequent complications of meningitis despite effective antibiotic treatment. This suggests that pathogen-independent inflammatory mechanisms may play an important role in the course of this illness. Neutrophil granulocytes form the primary immune defense in meningitis. Once activated, these cells release(More)
In a prospective study elastase α1-proteinase inhibitor (Eα1PI), polymorphonuclear (PMN) count, the immature to total neutrophil count ratio (I/T ratio), and C-reactive protein (CRP) were analysed in 74 patients (76 cases) with neonatal septicaemia at the time of initial clinical symptoms. At that early stage of the disease, 94% of the patients had abnormal(More)
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