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  • Michael D. Godeny, Jacqueline Sayyah, +4 authors Peter P. Sayeski
  • Biology, Medicine
  • Cellular signalling
  • 2007 (First Publication: 1 March 2007)
  • Previous work has suggested that the protein tyrosine phosphatase, SHP-2, may act to facilitate angiotensin II (Ang II)-mediated, Jak2-dependent signaling. However, the mechanisms by which thisExpand
  • Jacqueline Sayyah, Andrew T. Magis, David A Ostrov, Robert William Allan, Raul C. Braylan, Peter P. Sayeski
  • Medicine, Biology
  • Molecular Cancer Therapeutics
  • 2008 (First Publication: 1 August 2008)
  • Jak2 tyrosine kinase is essential for animal development and hyperkinetic Jak2 function has been linked to a host of human diseases. Control of this pathway using Jak2-specific inhibitors wouldExpand
  • Juan Manuel Ortiz-Sánchez, Sara E. Nichols, Jacqueline Sayyah, Joan Heller Brown, James Andrew McCammon, Barry J. Grant
  • Medicine, Biology
  • PloS one
  • 2012 (First Publication: 16 July 2012)
  • Rho GTPases are conformational switches that control a wide variety of signaling pathways critical for eukaryotic cell development and proliferation. They represent attractive targets for drug designExpand
  • Jacqueline Sayyah, Kavitha Gnanasambandan, Sushama Kamarajugadda, Shigeharu Tsuda, Jennifer Caldwell-Busby, Peter P. Sayeski
  • Medicine, Biology
  • Cellular signalling
  • 2011 (First Publication: 1 November 2011)
  • Jak2 tyrosine kinase plays an important role in cytokine mediated signal transduction. There are 49 tyrosine residues in Jak2 and phosphorylation of some of these are known to play important roles inExpand