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The objective of this investigation was to distinguish which of the catalytic features of enzyme action is principally responsible for conferring the observed insensitivity of trout brain acetylcholinesterase (AChE; EC 3.1.1.7) to in vitro inhibition by organophosphates. The experimental design consisted of comparing the kinetic constants for the hydrolysis(More)
Two fetuses with severe anaemia due to rhesus incompatibility each received two early blood transfusions (between 23 and 25 weeks) by fetoscopy. The blood was given directly into an umbilical vessel, either at the umbilicus or at the placental cord insertion. Fetal blood samples were taken before and after transfusion to assess the haematological status of(More)
SETTING All 43 non-private hospitals in Malawi, which registered TB cases between 1 July 1999 and 30 June 2000. OBJECTIVES To determine 1) the characteristics, management and treatment outcome, 2) timing of the previous episode of TB, and 3) pattern of drug resistance in patients registered with recurrent smear-positive pulmonary TB. DESIGN(More)
PURPOSE To correlate clinically observed fluctuations in manifest refraction, visual acuity, keratometry, and intraocular pressure (IOP) with changes in the anterior corneal surface as measured by videokeratography in patients 10 years after radial keratotomy (RK). SETTING Four clinical centers in the United States that participated in the Prospective(More)
SETTING Ntcheu District, rural Malawi. OBJECTIVES 1) To locate smear-positive pulmonary tuberculosis patients who were identified during the first 6 months of 2000 but did not start treatment ('lost cases'); 2) to describe these patients' pathways to diagnosis, health status and socio-demographic characteristics; and 3) to explore why these patients did(More)
SETTING All non-private hospitals in Malawi that registered TB cases in 2001, during which there was a bus service for transporting sputum specimens to the Central Reference Laboratory (CRL) for mycobacterial culture and drug sensitivity testing (CDST). OBJECTIVES To determine the performance of the system of collecting and processing sputum specimens(More)
Fetal blood and amniotic fluid samples were obtained fetoscopically from 59 rhesus-isoimmunized pregnancies at 18 to 25 weeks' gestation. Fetal hemoglobin was measured and amniotic fluid optical density deviation at a wavelength of 450 nm determined. Two sets of normal reference values for optical density at 450 nm and fetal hemoglobin at 16 to 36 and 16 to(More)
Improper regulation of signaling in vascular smooth muscle cells (VSMCs) by angiotensin II (AngII) can lead to hypertension, vascular hypertrophy and atherosclerosis. The extent to which the homeostatic levels of the components of signaling networks are regulated through microRNAs (miRNA) modulated by AngII type 1 receptor (AT1R) in VSMCs is not fully(More)
SETTING The National TB Control Programme (NTP) of Malawi. OBJECTIVES To describe 1) the way in which a generic operational research project was developed and implemented by hospital TB officers (TBOs), 2) the outcome in terms of research work completed, data analysed and papers written up, and 3) the results of the research project. DESIGN A(More)