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Regional cortical thickness was evaluated using CIVET processing of 3D T1-weighted images (i) to compare the variation in cortical thickness between 33 participants with fetal alcohol spectrum disorders (FASD) aged 6-30 years (mean age 12.3 years) versus 33 age/sex/hand-matched controls, and (ii) to examine developmental changes in cortical thickness with(More)
A key area of weakness in individuals with fetal alcohol spectrum disorder (FASD) is working memory, thus the goal of this study was to determine whether teaching children (aged 4-11) with FASD verbal rehearsal would increase their memory. Rehearsal training has been effective in other populations with working memory difficulties, so we hypothesized that(More)
Keshan disease (KD) is an endemic cardiomyopathy associated with selenium deficiency. Recent studies indicate that glutathione peroxidase 1 (GPx1) mutation decreases GPx activity in myocardial cells and increases the risk of KD. To further clarify the correlation between GPx1 polymorphism and KD, we analyzed GPx1 polymorphism, blood selenium levels and(More)
BACKGROUND Children with Foetal Alcohol Spectrum Disorders (FASD) have significant impairments in memory, negatively affecting academics and daily functioning. PRIMARY OBJECTIVE To review published research on: (1) verbal and visual-spatial memory in children with FASD or prenatal alcohol exposure (PAE); (2) animal research on the impact of PAE on memory;(More)
Retinitis pigmentosa (RP) is a devastating form of retinal degeneration, with significant social and professional consequences. Molecular genetic information is invaluable for an accurate clinical diagnosis of RP due to its high genetic and clinical heterogeneity. Using a gene capture panel that covers 163 of the currently known retinal disease genes,(More)
OBJECTIVES Deficits in memory are well-documented in children with fetal alcohol spectrum disorders (FASD); however, one aspect of memory not yet studied in children with FASD is source monitoring. This study examined overall source monitoring ability and performance profiles of children with FASD compared to controls. METHOD Participants included 19(More)
OBJECTIVE Many children with Fetal Alcohol Spectrum Disorders (FASD) also have co-morbid ADHD. The goal of this study was to examine the impact of having a co-morbid ADHD diagnosis on FASD diagnostic results. We compared children with FASD to those with FASD and co-morbid ADHD across the neurobehavioral domains recommended by the Canadian Guidelines in the(More)
Children with fetal alcohol spectrum disorder (FASD) or prenatal alcohol exposure (PAE) frequently exhibit impairment on tasks measuring inhibition. The objective of this study was to determine if a performance-based relationship exists between psychometric tests and eye movement tasks in children with FASD. Participants for this dataset were aged 5-17(More)
Previous studies have demonstrated that children with Fetal Alcohol Spectrum Disorder (FASD) exhibit deficits in measures of eye movement control that probe aspects of visuospatial processing and working memory. The goal of the present study was to examine, in a large cohort of children with FASD, prenatal alcohol exposure (PAE) but not FASD, and typically(More)
BACKGROUND Previous research indicates that children with FASD have both memory and learning deficits. However, there is no consensus about whether the deficits identified from a pattern of impairment, and whether this pattern is consistent with the current theories regarding the organization of memory. Thus, the goal of this study was to further explore(More)