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An Altered T Cell Repertoire in MECL-1-Deficient Mice1
Immunoproteasome subunits low-molecular mass polypeptide (LMP)2 and LMP7 affect Ag presentation by MHC class I molecules. In the present study, we investigated the function of the third immunosubunitExpand
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Reduced Immunoproteasome Formation and Accumulation of Immunoproteasomal Precursors in the Brains of Lymphocytic Choriomeningitis Virus-Infected Mice
Tissue inflammation is accompanied by the cytokine-mediated replacement of constitutive proteasomes by immunoproteasomes that finally leads to an optimized generation of MHC class I restrictedExpand
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Immunoproteasomes are essential for survival and expansion of T cells in virus‐infected mice
Immunoproteasomes containing the IFN‐inducible subunits β1i (LMP2), β2i (MECL‐1) and β5i (LMP7) alter proteasomal cleavage preference and optimize the generation of peptide ligands of MHC class IExpand
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Why the Structure but Not the Activity of the Immunoproteasome Subunit Low Molecular Mass Polypeptide 2 Rescues Antigen Presentation
The proteasome is responsible for the generation of most epitopes presented on MHC class I molecules. Treatment of cells with IFN-γ leads to the replacement of the constitutive catalytic subunits β1,Expand
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Interferometric sensor for absolute distance measurements based on an external cavity semiconductor laser
A sensor principle is presented that uses an antireflection coated diode laser together with a technical surface as an external Fabry-Perot resonator. Modulation of the diode current creates aExpand
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