Jacqueline Friedmann

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The crystalline cell-surface (S) layer sgsE of Geobacillus stearothermophilus NRS 2004/3a represents a natural protein self-assembly system with nanometer-scale periodicity that is evaluated as a combined carrier/patterning element for the conception of novel types of biocatalyst aiming at the controllable display of biocatalytic epitopes, storage(More)
Crystalline monomolecular cell surface layers, S-layers, are one of the most common outermost cell envelope components of the prokaryotic organisms (bacteria and archaeda) that protects them from competitive habitats. Since isolated S-protein subunits are able to re-assemble into crystalline arrays on lipid films and solid supports making biomimetic(More)
Because of its importance to an understanding of the mechanisms involved in the conversion of prothrombin to thrombin, the inhibitory properties of soybean trypsin inhibitor on this system were investigated. Kinetic studies showed that the inhibitor participates in a bimolecular reversible reaction with one of the components of the prothrombin-thrombin(More)
Amyloid fibrils are commonly observed to adopt multiple distinct morphologies, which eventually can have significantly different neurotoxicities, as e.g. demonstrated in case of the Alzheimer peptide. The architecture of amyloid deposits is apparently also determined by the stereochemistry of amino acids. Post-translational changes of the chirality of(More)
The amino acid composition of purified human plasma prothrombin was determined by ion exchange chromatography. In some cases, the carbohydrate composition was also estimated. Seven preparations, isolated in two different laboratories and finally purified by two different methods, were studied. Within experimental error, all the preparations had the same(More)
A comparison has been made between the clotting activity (C) and TAMe esterase activity (E) during prothrombin activation and subsequent purification of human thrombin. A limited number of studies were made using bovine thrombin for comparison purposes. Under certain circumstances, the ratio of C to E for human thrombin is not constant, particularly upon(More)