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The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining.

• Robert Hromas, Justin Wray, +6 authors Elizabeth A. Williamson
• DNA repair
• 2008

Transposase domain proteins mediate DNA movement from one location in the genome to another in lower organisms. However, in human cells such DNA mobility would be deleterious, and therefore the vast… (More)

Cytotoxic activity of the titanium alkoxide (OPy)2Ti(4AP)2 against cancer colony forming cells

• Elizabeth A. Williamson, Timothy J. Boyle, +4 authors Robert Hromas
• Investigational New Drugs
• 2010

A novel family of titanium alkoxides with two stable pyridinemethoxide moieties bound to a titanium metal center were synthesized and tested for cytotoxic activity on a variety of cancer cell lines… (More)

Expression levels of the human DNA repair protein metnase influence lentiviral genomic integration.

• Elizabeth A. Williamson, Jacqueline Farrington, +5 authors Robert Hromas
• Biochimie
• 2008

We recently identified a Transposase domain protein called Metnase, which assists in repairing DNA double-strand breaks (DSB) via non-homologous end-joining (NHEJ), and is important for foreign DNA… (More)

The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations.

• Justin Wray, Elizabeth A. Williamson, +7 authors Robert Hromas
• Cancer genetics and cytogenetics
• 2010

Chromosomal translocations are common in leukemia, but little is known about their mechanism. Metnase (also termed SETMAR) is a fusion of a histone methylase and transposase protein that arose… (More)

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