Jacqueline English

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Purpose: d -Limonene is a natural monoterpene with pronounced chemotherapeutic activity and minimal toxicity in preclinical studies. A phase I clinical trial to assess toxicity, the maximum tolerated dose (MTD) and pharmacokinetics in patients with advanced cancer was followed by a limited phase II evaluation in breast cancer. Methods: A group of 32(More)
Preclinical studies have shown that the vitamin D analogue EB 1089 has significantly less calcaemic activity than its parent compound 1,25-dihydroxyvitamin D (1,25(OH)2D3) and significant anti-tumour activity. This phase I trial was designed to evaluate the calcaemic effect of the drug in patients with advanced cancer. EB 1089 was given to 36 patients with(More)
In a move to reduce the number of deaths from breast cancer there was a shift in emphasis in 1991 away from breast self-examination to breast awareness. This article takes a close look at the background to this shift, the conflicting messages with regards to breast awareness, and the need to re-educate and empower nurses and other health professionals with(More)
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