Jacqueline Brodie

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The proto-oncogene product c-Myc can induce cell growth and proliferation. It regulates a large number of RNA polymerase II-transcribed genes, many of which encode ribosomal proteins, translation factors and other components of the biosynthetic apparatus. We have found that c-Myc can also activate transcription by RNA polymerases I and III, thereby(More)
This paper describes the design and evaluation of a computer-based communication system called 'TalksBac' with four nonfluent adults with aphasia. Despite the increased availability of computer-based augmentative and alternative communication (AAC) devices, their use with adults with aphasia is limited as few devices have been designed for this population.(More)
The androgen receptor (AR) is a ligand-activated transcription factor that recognises and binds to specific DNA response elements upon activation by the steroids testosterone or dihydrotestosterone. In vitro, two types of response element have been characterised - non-selective elements that bind the androgen, glucocorticoid and progesterone receptors, and(More)
The uptake of mobile phones in the UK has increased exponentially in the past two years, indicating that a wider range of users are now utilising mobile technologies in different contexts than ever before. Still little is known about how mobile technologies are used amongst different populations in specific contexts and this research addresses the context(More)
The lack of standard assessment criteria for reliably comparing usability evaluation methods (UEMs) is an important gap in HCI knowledge. Recently, metrics for assessing thoroughness, validity, and effectiveness of UEMs, based on user data, have been proposed to bridge this gap. This paper reports our findings of applying these proposed metrics in a study(More)
We investigated what mobile workers do when they are mobile to achieve their communication goals, using contextual interviews and ethnographically inspired observations in a variety of settings. Implications for the design of mobile technology were extracted from the raw data collected in the fieldwork using such novel design techniques as 'Day in the Life'(More)
INTRODUCTION The uptake of mobile phones in the UK has increased exponentially in the past two years, indicating that a wider range of users are now utilising mobile technologies in different contexts than ever before. Still little is known about how mobile technologies are used amongst different populations in specific contexts and this research addresses(More)
This report investigates time management in COTS based distributed simulation using HLA. Discussions are limited to discrete event simulation and conservative algorithms. The COTS Simulation Package Emulator (CSPE) is used as an experimental tool. Its architecture is modified to use HLA as middleware. A time management algorithm is designed and implemented(More)