Jacqueline Bourdeau

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Absrtact. In their paper[14], Bourdeau and Mizoguchi foresaw a framework for ontology-based intelligent systems. Although it took longer years than their expectation, the ontology they have been developing is now released for evaluation with the help of the second author. Ontology building is a labor-intensive process and it is rarely perfect. Our(More)
This paper discusses long-term prospects of AI-ED research with the aim of giving a clear view of what we need for further promotion of the research from both the AI and ED points of view. An analysis of the current status of AI-ED research is done in the light of intelligence, conceptualization, standardization and theory-awareness. Following this, an(More)
In this paper, we present an ontology of educational theories their relation to learning design. This ontology takes into account learning design (LD) specifications such as OUNL-EML and IMS-LD at the conceptual level (1), semantic web standards such as OWL at the formal level (2), as well as JAVA standards at the implementation level (3). This ontology is(More)
Studies of cortical proximal nephrons and plasma membrane vesicles suggest that a Ca-Na exchanger regulates intracellular Ca2+ concentration ([Ca2+]i) in renal tubular cells. We tested this hypothesis in isolated perfused rabbit connecting segments by measuring [Ca2+]i with fura-2. Within 2 min of replacing bath NaCl with mannitol, [Ca2+]i rose from a base(More)
Thick ascending limbs of Henle's loop were dissected from rabbit kidneys and perfused in vitro. Unidirectional transepithelial calcium fluxes from lumen-to-bath and bath-to-lumen were measured with 45Ca using different solutions that caused the transepithelial voltage to vary over a wide range. With lumen-positive voltages there was net calcium absorption(More)
We evaluated the acute effects of varying dialysate calcium concentration on plasma concentrations and dialyzer fluxes of calcium and phosphorus in adult hemodialysis patients. Seven individuals with stable end-stage renal failure were dialyzed 4 hours, three times weekly. The effects of dialysates containing 1.75, 1.25, or 0.75 mmol/L (70.1, 50.1, or 30.1(More)
Renal tubular reabsorption of phosphate is critical to the maintenance of phosphate homeostasis in mammals, and the brush-border membrane Na-P(i) cotransport systems in proximal tubules play a major role in this process. We have isolated a cDNA encoding a mouse sodium-dependent phosphate transport protein (Npt1), which is expressed primarily in the kidney.(More)
Cortical thick ascending limbs of Henle's loop were dissected from rabbit kidneys and perfused in vitro. Unidirectional transepithelial calcium fluxes from lumen-to-bath and bath-to-lumen were measured with 45Ca. The tubules were bathed in 150 mM sodium and perfused with 60 mM sodium to simulate conditions in the cortical thick ascending limb in vivo.(More)
Urinary calcium excretion is regulated homeostatically. Regulation is achieved, in part, by the action of parathyroid hormone on Ca2+ absorption in the distal nephron. Parathyroid hormone increases Ca2+ absorption in the cortical portion of the thick ascending limb of Henle's loop in all species studied, in the murine distal convoluted tubule, and in the(More)