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The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
TLDR
This work proposes that USP9X is a major tumour suppressor gene with prognostic and therapeutic relevance in PDA, and finds that loss of Usp9x enhances transformation and protects pancreatic cancer cells from anoikis. Expand
Clinical Significance of the Genetic Landscape of Pancreatic Cancer and Implications for Identification of Potential Long-term Survivors
TLDR
Determinations of the status of the 4 major driver genes in pancreatic cancer, and specifically the extent to which they are coexistent in an individual patients cancer, provides distinct information regarding disease progression and survival that is independent of clinical stage and treatment status. Expand
Genetically Defined Subsets of Human Pancreatic Cancer Show Unique In Vitro Chemosensitivity
TLDR
The hypothesis that genetic subsets of pancreatic cancer exist, and these genetic backgrounds may permit one to personalize the chemotherapy of Pancreatic cancer in the future, is supported. Expand
Pancreatic cancer genomics: insights and opportunities for clinical translation
TLDR
Current knowledge of the genetics and genomics of pancreatic cancer from its inception to metastatic colonization is summarized and examples of how this information can be translated into the clinical setting for therapeutic benefit and personalized medicine are provided. Expand
The deubiquitinase USP 9 X suppresses pancreatic ductal adenocarcinoma
Pedro A. Pérez-Mancera, Alistair G. Rust, Louise van der Weyden, Glen Kristiansen, Allen Li, Aaron L. Sarver, Kevin A. T. Silverstein, Robert Grützmann, Daniela Aust, Petra Rümmele, Thomas Knösel,Expand
A new branch on the tree: next-generation sequencing in the study of cancer evolution.
TLDR
A clearer understanding of those alterations that undergo positive and negative selection throughout carcinogenesis and leading to metastatic dissemination would provide a boon not only to the understanding of cancer evolution, but to the development of potential targets for therapeutic intervention as well. Expand
Origin of metastases: Subspecies of cancers generated by intrinsic karyotypic variations
TLDR
It is concluded that metastases are individual autonomous species differing from each other and parental cancers in species-specific karyotypes and phenotypes, generated from parental cancers by multiple simultaneous karyotypic rearrangements, much like new species. Expand
Corrigendum: The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
TLDR
This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, like in the previous version of this paper. Expand
Abstract 4006: Smad6 upregulation provides an alternative mechanism for BMP inactivation in SMAD4 wild type pancreatic cancers.
TLDR
Preliminary studies in vitro support a metastasis-promoting function of Smad6: Smad 6 overexpression is associated with increased levels of proliferation, migration, and invasion in SMAD4-intact pancreatic cancer cell lines. Expand
Abstract 5318: DPC4 loss results in the activation of alternative oncogenic pathways in pancreatic cancer
TLDR
It is hypothesized that DPC4 loss may be driving pancreatic cancer metastasis by forcing the TGF-β signal down an alternative pathway, and the Pi3K and ERK signaling pathways in cells lacking DPC 4 are considered as therapeutic targets. Expand
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