Jacqueline A Gilbert

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Neurotensin, an endogenous tridecapeptide, produces a potent, naloxone-insensitive antinociceptive response when it is microinjected into the periaqueductal gray region of the rat brainstem. In the present study, the ED50 for neurotensin in inducing antinociception was 1.5 nmol, two times more potent than morphine. We sought to find whether neurotensin's(More)
IntroductIon The World Wide Web (WWW) was initially written as a " point and click hypertext editor " (Berners-Lee, 1998, para. 2). Used as a search device by academia and industry, it has over the years experienced both rapid and explosive growth. Earlier incarnations of the World Wide Web were known as " Web 1.0. " Since its inception however the internet(More)
Traditional classroom delivery has experienced a complete overhaul with the advent of Web 2.0 techniques for delivering course material. The Socratic method of teaching can now be effectively accomplished in an online discussion forum, a synchronous chat session, virtual environments, or in a wiki format. All of these innovative technologies are part of an(More)
Recent headlines highlight the literal toxicity spewing from companies such as BP (oil spill), Hillandale Farms (salmonella poisoning), and W.R. Grace (vermiculite/asbestos poisoning). These incidents bring to mind an earlier rash of visible and high profile executives from such companies as Enron, WorldCom, and Tyco, who made headlines because of their(More)
Neurotensin(8-13), the carboxyl-terminal portion of neurotensin, is 4-50 times more potent than native neurotensin in binding to intact neuroblastoma N1E-115 cells and human brain tissue and in stimulation of intracellular cyclic GMP production and inositol phospholipid hydrolysis in clone N1E-115 (Gilbert JA and Richelson E, Eur J Pharmacol 99: 245-246,(More)
Murine neuroblastoma clone N1E-115, which possesses receptors for neurotensin mediating the formation of intracellular cyclic GMP and the stimulation of inositol phospholipid hydrolysis, exhibited only partial desensitization to neurotensin. This result led to the observation that neurotensin was very rapidly degraded by intact N1E-115 cells. In experiments(More)
Synthesis of methionine5-enkephalin by intact cells of murine neuroblastoma clone N1E-115 has been demonstrated both immunocytochemically and biochemically. In addition, N1E-115 cells possess homogeneous enkephalin (delta) receptors which inhibit prostaglandin E1-induced intracellular cyclic AMP formation. An assay was developed for measuring de novo(More)
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