Jacobijn Gussekloo

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CONTEXT Despite the equivocal outcomes of randomized controlled trials, general clinical opinion favors screening and treatment of elderly individuals with subclinical thyroid disorders. OBJECTIVES To determine whether subclinical thyroid dysfunction should be treated in old age and the long-term impact of thyroid dysfunction on performance and survival(More)
It has been suggested that the metabolic syndrome and type 2 diabetes are manifestations of the inflammatory host response. This host response is orchestrated by the production of pro- and anti-inflammatory cytokines that are under genetic control. We therefore hypothesized that a low production capacity of interleukin-10 (IL-10), a centrally operating(More)
BACKGROUND Successful aging is a worldwide aim, but it is less clear which indicators characterize elderly persons as successfully aged. We explored the meaning of successful aging from 2 perspectives. METHODS Analysis of data from the first cross-sectional part of the longitudinal Leiden 85-plus Study, conducted in Leiden, the Netherlands. All(More)
OBJECTIVE To examine the temporal relation between depression and cognitive impairment in old age. DESIGN Prospective, population based study with four years of follow up. SETTING City of Leiden, the Netherlands. PARTICIPANTS 500 people aged 85 years at recruitment. MAIN OUTCOME MEASURES Annual assessments of depressive symptoms (15 item geriatric(More)
OBJECTIVES To investigate the performance of classic risk factors, and of some new biomarkers, in predicting cardiovascular mortality in very old people from the general population with no history of cardiovascular disease. DESIGN The Leiden 85-plus Study (1997-2004) is an observational prospective cohort study with 5 years of follow-up. SETTING General(More)
We tested the hypothesis that an additional effort to increase the response rate would diminish selection bias in a community-based cohort study. In the Leiden 85-plus Study, all subjects of the town of Leiden who had reached their 85th birthday were informed of the study by mail and then asked to participate by telephone. In an additional recruitment(More)
BACKGROUND Various studies support the notion that the clinical picture of depression in the oldest old differs from that in younger elderly. Moreover, withstanding the serious negative effects of depression on well being and functioning, the detection rate of depression in several medical settings is low. METHODS Prevalence of depression, correlates and(More)
OBJECTIVES To compare the value of dual tasking in predicting falling in the general population of oldest old with that of easy-to-administer single tasks. DESIGN Prospective population-based follow-up study. SETTING Municipality of Leiden, the Netherlands. PARTICIPANTS Representative cohort of 380 individuals, all aged 85 at baseline. MEASUREMENTS(More)
BACKGROUND The metabolic syndrome is a cluster of risk factors including hypertension, obesity, dyslipidemia, and impaired glucose metabolism, associated with cardiovascular disease. The metabolic syndrome also appears to predispose to cognitive dysfunction and dementia. In this study the association between the metabolic syndrome and cognitive function was(More)
BACKGROUND In people with chronic obstructive pulmonary disease (COPD) there is considerable variation in symptoms, limitations and well-being, which often complicates medical care. To improve quality of life (QoL) and exercise tolerance, while reducing the number of exacerbations, a multidisciplinary program including different elements of care is needed.(More)