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- Bas Vroling, Marijn P. A. Sanders, +6 authors Gert Vriend
- Nucleic Acids Research
- 2011
The GPCRDB is a Molecular Class-Specific Information System (MCSIS) that collects, combines, validates and disseminates large amounts of heterogeneous data on G protein-coupled receptors (GPCRs). The… (More)
- Raoul Frijters, Bart Heupers, +5 authors Wynand Alkema
- Nucleic Acids Research
- 2008
Medline is a rich information source, from which links between genes and keywords describing biological processes, pathways, drugs, pathologies and diseases can be extracted. We developed a publicly… (More)
- Wilco W. M. Fleuren, Stefan Verhoeven, +5 authors Wynand Alkema
- Nucleic Acids Research
- 2011
In this article, we present CoPub 5.0, a publicly available text mining system, which uses Medline abstracts to calculate robust statistics for keyword co-occurrences. CoPub was initially developed… (More)
- Raoul Frijters, Marianne van Vugt, Ruben Smeets, René C. van Schaik, Jacob de Vlieg, Wynand Alkema
- PLoS Computational Biology
- 2010
The scientific literature represents a rich source for retrieval of knowledge on associations between biomedical concepts such as genes, diseases and cellular processes. A commonly used method to… (More)
- Tim Hulsen, Peter M. A. Groenen, Jacob de Vlieg, Wynand Alkema
- Nucleic Acids Research
- 2009
Phylogenetic patterns show the presence or absence of certain genes in a set of full genomes derived from different species. They can also be used to determine sets of genes that occur only in… (More)
- David J. Wood, Jacob de Vlieg, Markus Wagener, Tina Ritschel
- Journal of Chemical Information and Modeling
- 2012
Bioisosteres have been defined as structurally different molecules or substructures that can form comparable intermolecular interactions, and therefore, fragments that bind to similar protein… (More)
- Marijn P. A. Sanders, Stefan Verhoeven, +5 authors Jan P. G. Klomp
- Journal of Chemical Information and Modeling
- 2011
G-protein coupled receptors (GPCRs) are important drug targets for various diseases and of major interest to pharmaceutical companies. The function of individual members of this protein family can be… (More)
- Tim Hulsen, Jacob de Vlieg, Jack A. M. Leunissen, Peter M. A. Groenen
- BMC Bioinformatics
- 2006
BackgroundIn the past years the Smith-Waterman sequence comparison algorithm has gained popularity due to improved implementations and rapidly increasing computing power. However, the quality and… (More)
- Marijn P. A. Sanders, Wilco W. M. Fleuren, +4 authors Jan P. G. Klomp
- BMC Bioinformatics
- 2010
BackgroundG-protein coupled receptors (GPCRs) are involved in many different physiological processes and their function can be modulated by small molecules which bind in the transmembrane (TM)… (More)
- Marijn P. A. Sanders, Arménio Jorge Moura Barbosa, +4 authors Alberto Del Rio
- Journal of Chemical Information and Modeling
- 2012
The pharmacophore concept is of central importance in computer-aided drug design (CADD) mainly because of its successful application in medicinal chemistry and, in particular, high-throughput virtual… (More)