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  • Jacob T. Bush, Robert K. Leśniak, +7 authors Christopher J. Schofield
  • Medicine, Chemistry
  • Chemical communications
  • 2019
  • We describe covalently binding modulators of the activity of human prolyl hydroxylase domain 2 (PHD2) and studies towards a strategy for photocapture of PHD2 substrates. Reversible active siteContinue Reading
  • Jacob T. Bush, Mun Chiang Chan, Shabaz Mohammed, Christopher J. Schofield
  • Medicine
  • Chembiochem : a European journal of chemical…
  • 2020 (First Published: 10 January 2020)
  • The hypoxia-inducible factors (HIFs) are key transcription factors in determining cellular responses involving alterations in protein levels in response to limiting oxygen availability in animalContinue Reading