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PURPOSE Most patients with advanced pancreas cancer experience pain and must limit their daily activities because of tumor-related symptoms. To date, no treatment has had a significant impact on the disease. In early studies with gemcitabine, patients with pancreas cancer experienced an improvement in disease-related symptoms. Based on those findings, a(More)
PURPOSE To assess the effect of gemcitabine in patients with metastatic pancreas cancer that had progressed despite prior treatment with 5-FU. PATIENTS AND METHODS Seventy-four patients were enrolled in this multicenter trial. Alleviation of cancer-related symptoms was the primary endpoint. Sixty-three patients completed a pain stabilization period and(More)
BACKGROUND Risk factors for contralateral breast cancer (CBC) may indicate a benefit for contralateral prophylactic mastectomy (CPM) at the time of unilateral mastectomy for breast cancer. The purpose of this study is to evaluate the efficacy of CPM in preventing CBC. METHODS sixty-four patients undergoing CPM and a control group of 182 patients not(More)
BACKGROUND Because inflammatory breast cancer (IBC) has been viewed as a malignancy with a poor likelihood of longterm survival, few women have been offered esthetic reconstruction after mastectomy for IBC. Recent advances in multimodality therapy have improved the outcomes for women with this disease. The purpose of this review was to assess the results of(More)
In a blinded controlled study, 58 consecutive patients with definite left atrial enlargement (M-mode dimension of at least 45 mm) were followed up after 1-2 years. The aim of the study was to examine the following: (a) the prospective risk of developing atrial fibrillation (AF); and (b) the effect of the heart rhythm on the left atrial size. Of 36 patients(More)
The effects on latent inhibition (LI; a delay in conditioning when a CS has been pre-exposed without consequences) of repeated restraint stress and the anxiolytic drug diazepam were examined in C57BL/6 mice to know whether previous aversive events or anxiolysis are factors determining the expression of LI. The LI model was optimized for this strain(More)
The purpose is to study relative turbulent diffusion under controlled, reproducible conditions in the laboratory in order to estimate the constant C in Richardson-Obukhov's law. We get C ≈ 0.4 – 0.6. We furthermore measure the distance-neighbour function, which is the probability density function of the separation of two fluid particles that are initially(More)
When a container of fluid is oscillated vertically, capillary waves develop on the surface if the amplitude exceeds a critical value. Experimentally one finds that the motion of small particles on the surface of the fluid is close to Brownian. Here we study the relative motion of particle pairs. The experiment establishes that particle motion is strongly(More)
This study provides data on plasma volume (PV), extracellular volume (ECV) and renal function in 8 untreated patients with acute myocardial infarction (AMI). At day 2 and day 10 after AMI, glomerular filtration rate (GFR), urinary excretion rate of water (Vu), sodium clearance (CNa) and lithium clearance (CLi) were used for assessing reabsorption rates of(More)
We examine particle trajectories in capillary waves formed on a water surface subject to vertical vibrations. We focus on the role of a distinct length scale present in our experiment, namely, the wavelength l of the surface waves. We observe non-Brownian particle trajectories with a fractal dimension D different from the random walk value D ෇ 2. A(More)