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The interpretation of large-scale protein network data depends on our ability to identify significant substructures in the data, a computationally intensive task. Here we adapt and extend efficient techniques for finding paths and trees in graphs to the problem of identifying pathways in protein interaction networks. We present linear-time algorithms for(More)
Polychlorinated biphenyls (PCBs), a structurally diverse group of environmental pollutants, are effective promoters in two-stage cancer models, which implies that epigenetic mechanisms are involved. Inhibition of gap junctional intercellular communication (GJIC) belongs among critical epigenetic events of tumor promotion. We determined the relative(More)
Current generation worms have caused considerable damage, despite their use of unsophisticated scanning strategies for detecting vulnerable hosts. A number of adaptive techniques have been proposed for quarantining hosts whose behaviour is deemed suspicious. Such techniques have been proven to be effective against fast scanning worms. However, worms could(More)
Dicumyl peroxide (di-CuOOH) and benzoyl peroxide (BzOOH) act as tumor promoters in SENCAR mice, whereas di-tert-butylhydroperoxide does not. Tumor promotion requires the removal of growth suppression by inhibition of gap junctional intercellular communication (GJIC) and the induction of mitogenic intracellular pathways. We showed that di-CuOOH and BzOOH(More)
This paper describes the current state of knowledge of methods for analysing gene structure and localization. Illustrations are given of the preparation of complementary DNA libraries and their screening by positive-negative selection, the use of synthetic oligodeoxynucleotides and the use of antibodies. Analysis of the EGF precursor is used as an example(More)
Identification of candidate cancer therapeutic small molecule activators of the TRAIL gene was the primary goal that led to identification of TIC10 (later renamed as ONC201). Of >1000 molcules screened, ONC201 appeared to cause dual inhibition of p-ERK and p-AKT, nuclear translocation of Foxo3a and associated increase of TNF Related Apoptosis Inducing(More)
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