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The dystrophin-associated glycoprotein complex (DGC) is found at the muscle fiber sarcolemma and forms an essential structural link between the basal lamina and internal cytoskeleton. In a set of muscular dystrophies known as the dystroglycanopathies, hypoglycosylation of the DGC component α-dystroglycan results in reduced binding to basal lamina(More)
One of the perennial challenges of ethical theory has been to provide an answer to a number of views that appear to undermine the importance of ethical questions. We may refer to such views collectively as " deflationary ethical theories. " These include theories, such as nihilism, according to which no action is better than any other, as well as(More)
The phenomenon of disagreement has recently been brought into focus by the debate between contextualists and relativist invariantists about epistemic expressions such as 'might', 'probably ', indicative conditionals, and the deontic 'ought'. Against the orthodox contextualist view, it has been argued that an invariantist account can better explain apparent(More)
Currently, the most popular views about how to update de se or self-locating beliefs entail the one-third solution to the Sleeping Beauty problem. 1 Another widely held view is that an agent's credences should be countably additive. 2 In what follows, I will argue that there is a deep tension between these two positions. For the assumptions that underlie(More)
Cognitivism about practical reason is the view that intentions involve beliefs, and that the rational requirements on intentions can be explained in terms of the rational requirements on the beliefs that figure in intentions. In particular, cognitivists about practical reason have sought to provide cognitive explanations of two basic requirements of(More)
1 We seem to talk about repeatable artworks, such as symphonies, plays, films, dances, and so on, all the time. We say things like, " The Moonlight Sonata has three movements " and " Duck Soup makes me laugh ". But how are these sentences to be understood? On a simple treatment of these sentences, they have ordinary, subject-predicate form. The subject 2(More)
Fission cases, in which one person appears to divide into two persons, pose a serious challenge to many assumptions of commonsense ethics. Chief among these assumptions is the idea that self-interest is an important source of reasons. We normally think that something like the following is true: Self-Interest Thesis: For any person S, and any two(More)
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