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The shape and focal properties (spherical aberration) of the ocular lens of hatchling, yearling and adult clearnose skates (Raja eglanteria) were examined. In contrast to the spherical shape of the typical teleost lens, the lens of the clearnose skate is slightly aspherical; equatorial diameter being greater than axial diameter. The asphericity is(More)
A recent study involving Abbe and Pulfrich refractometry analyses the dispersion of the human lens and the ocular media of a number of vertebrates. In general, the lens and, to a lesser extent, the cornea, are more dispersive than expected at wavelengths below 500 nm. The dispersion findings of this study were used in conjunction with reduced eye parameters(More)
Substantial amounts of myopia can be induced in chicks by depriving the eye of clear vision for a period of 2 weeks after hatching. Previous work has primarily involved unilateral visual deprivation. Experiments described here include bilateral visual deprivation involving an opaque goggle over one eye and a translucent goggle over the other. The results(More)
Application of a translucent goggle over the chick eye on the first day after hatching led to the development of myopia. By the 14th day, the mean refractive error was about -10.0 D. Significant increases in axial and equatorial diameters were observed when the treated eyes were compared with untreated contralateral eyes. The lens did not appear to be(More)
PURPOSE Smad3, a mediator of TGF-beta signaling has been shown to be involved in the epithelial-to-mesenchymal transformation (EMT) of lens epithelial cells in a lens injury model. In this study, the role of Smad3 in anterior subcapsular cataract (ASC) formation was investigated in a transgenic TGF-beta/Smad3 knockout mouse model. METHODS TGF-beta1(More)
The continued peripheral growth of the lens, resulting in the concentration of older tissue toward the center, has the important optical consequence of producing a lens of variable refractive index. An approach consisting of the projection of fine laser beams through excised lenses in physiological solution has been used for in vitro study of lens optical(More)