Jacob Brogren

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INTRODUCTION Perfusion measurement by arterial spin labeling (ASL) techniques is well suited for pharmaceutical magnetic resonance imaging (phMRI) studies to investigate how drugs change the cerebral perfusion status and further, neuronal activity. MATERIALS AND METHOD Twelve healthy normal male volunteers participated in the study which was based on a(More)
During the last 10 years the European Medicines Agency (EMA) organized a number of workshops on modeling and simulation, working towards greater integration of modeling and simulation (M&S) in the development and regulatory assessment of medicines. In the 2011 EMA - European Federation of Pharmaceutical Industries and Associations (EFPIA) Workshop on(More)
L. E. Nordin, T-Q. Li, J. Brogren, N. Sjögren, K. Hannesdottir, J. Wang, and P. Julin Diagnostic Medical Physics, Karolinska University Hospital, Huddinge, Stockholm, Sweden, Clinical Science, Intervention and Technology, Division of Medical Imaging and Technology, Karolinska Institute, Stockholm, Sweden, AstraZeneca R&D Neuroscience, Södertälje, Sweden,(More)
OBJECTIVE The use of the standard procedure for managing overdoses with immediate release (IR) paracetamol is questionable when applied to overdoses with modified release (MR) formulations. This study describes the pharmacokinetics of paracetamol and the clinical outcomes following overdoses with a MR formulation. METHODS Medical records including(More)
Overdose of modified-release paracetamol calls for changed treatment routines. New guidelines from the Swedish Poisons Information Centre  The sales of modified-release paracetamol tablets are steadily increasing in Sweden as are the number of overdose cases with this formulation. The Swedish Poisons Information Centre has noted that the standard treatment(More)
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