Jacky Bernard

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Tumor growth promotes the expansion of CD4+CD25+ regulatory T (T reg) cells that counteract T cell-mediated immune responses. An inverse correlation between natural killer (NK) cell activation and T reg cell expansion in tumor-bearing patients, shown here, prompted us to address the role of T reg cells in controlling innate antitumor immunity. Our(More)
HIV type 1 (HIV-1) not only directly kills infected CD4 ؉ T cells but also induces immunosuppression of uninfected T cells. Two immunosuppressive proteins, inter-feron ␣ (IFN␣) and extracellular Tat, mediate this process because specific antibodies against these proteins prevent generation of suppressor cells in HIV-1-infected peripheral blood mononuclear(More)
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