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PURPOSE To develop a novel dose optimization algorithm for improving the sparing of critical structures during gamma knife radiosurgery by shaping the plug pattern of each individual shot. METHOD AND MATERIALS We first use a geometric information (medial axis) aided guided evolutionary simulated annealing (GESA) optimization algorithm to determine the(More)
A method for selectively inducing apoptosis in tumor nodules is presented, with close-to-cellular level resolution, using 3D-resolved widefield temporal focusing illumination. Treatment times on the order of seconds were achieved using Verteporfin as the photosensitizer, with doses of 30 μg ml(-1) and below. Results were achieved on both 2D and 3D cell(More)
Background: This study evaluated the dosimetric impact of various treatment techniques as well as collimator leaf width (2.5 vs 5 mm) for three groups of tumors – spine tumors, brain tumors abutting the brainstem, and liver tumors. These lesions often present challenges in maximizing dose to target volumes without exceeding critical organ tolerance.(More)
An intensity based six-degree image registration algorithm between cone-beam CT (CBCT) and planning CT has been developed for image-guided radiation therapy (IGRT). CT images of an anthropomorphic chest phantom were acquired using conventional CT scanner and corresponding CBCT was reconstructed based on projection images acquired by an on-board imager(More)
Knowledge Modeling for the Outcome of Brain Stereotactic Radiosurgery by Jillian E Hauck Medical Physics Graduate Program Duke University Date:_______________________ Approved: ___________________________ Q. Jackie Wu, Co-Supervisor ___________________________ John Kirkpatrick, Co-Supervisor ___________________________ Nan-kuei Chen An abstract of a thesis(More)
Stepped leaf edges are the major limitation of conforming to the prescribed treatment contour defined by the conventional multileaf collimator (MLC), which produces a scalloped dose pattern. The commercial HD-270 MLC (HDI) technique provides a software solution of the conventional MLC to achieve smoothed edge and optimal penumbra of the MLC shaped field. We(More)