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The Huxley 1957 model of cross-bridge cycling accounts for the shortening force-velocity curve of striated muscle with great precision. For forced lengthening, however, the model diverges from experimental results. This paper examines whether it is possible to bring the model into better agreement with experiments, and if so what must be assumed about the(More)
1. Stretching a contracting muscle leads to greater mechanical work being done during subsequent shortening by its contractile component; the mechanism of this enhancement is not known. 2. This mechanism has been investigated here by subjecting tetanized frog muscle fibres to ramp stretches followed by an isotonic release against a load equal to the maximum(More)
The FVB mouse is used extensively in transgenic research because of its defined inbred background, superior reproductive performance, and prominent pronuclei, which facilitate microinjection of genomic material. Seizures associated with a known mutation and seizure-susceptible inbred strains are well documented in mice; however, to the authors' knowledge,(More)
1 The actions of 4-(2-hydroxy-3-isopropylaminopropoxy) phenyl acetamide (ICI 66082), a new beta-adrenoceptor blocking drug, on the twitch response of the isolated papillary muscle of the rabbit and on dP/dt max and free heart rate of a denervated dog heart preparation, are described.2 ICI 66082 (up to 1 mg/ml) did not produce any depression of the twitch(More)
BACKGROUND AND PURPOSE The purpose of this study was to examine changes in gait and ankle motor performance in a group of patients with chronic lower extremity hemiplegia associated with treatment using a surface electromyography (SEMG)-based technology to induce movement (TIM)-type system. PARTICIPANTS Thirteen adult (average age, 44.8 years) volunteer(More)
A case of choroidal neurilemmoma is reported. After a period of clinical observation which included serial fundus photography and fluorescein angiography, during which time active growth was seen, the tumour was thought to be a malignant melanoma, and enucleation was considered the treatment of choice. Subsequent histological study revealed a neurilemmoma.(More)
This case report presents both the clinical and the histopathological features of the oldest patient on record with ophthalmic manifestations of Rosai-Dorfman Disease. An unusual feature, which has not been previously reported, is involvement of the cornea with subsequent perforation of the globe. The absence of lymphadenopathy is discussed.
1 The effects of propranolol, oxprenolol and practolol on the isometric twitch responses to electrical stimulation of isolated diaphragm muscles from the rat and of isolated papillary muscles from the rabbit are described.2 Depression of the twitch responses of the diaphragm muscle was produced by propranolol (20 mug/ml), by oxprenolol (100 mug/ml) and by(More)