Jackie Briggs

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Association studies using common sequence variants or single nucleotide polymorphisms (SNPs) may provide a powerful approach to dissect the genetic inheritance of common complex traits. Such studies necessitate the development of cost-effective, high throughput technologies for scoring SNPs. The method described in this paper for the co-detection of both(More)
The temperature-composition phase diagram of monomyristolein in water was constructed using x-ray diffraction. Low- and wide-angle diffraction patterns were collected from samples of fixed hydration as a function of temperature in the heating direction on x-ray-sensitive film and/or image plates. The phases identified in the system include the lamellar(More)
The temperature-composition phase diagram of monopentadecenoin, a monoacylglycerol with a cis monounsaturated fatty acid 15 carbon atoms long (C15:1c10) in water was constructed using x-ray diffraction. Low- and wide-angle diffraction patterns were collected from samples of fixed hydration as a function of temperature in the heating direction on(More)
BACKGROUND There is a need for innovative methodologies to identify and prioritize topics for health technology assessment (HTA). A pilot project to evaluate the methodology for specialty mapping was undertaken in the area of child and adolescent health. Two case studies are presented, in the area of sexually transmitted infections and acute pain. METHODS(More)
The homogeneous fluorescent immunoassay described above allows one to measure the brightness of fluorescently tagged carrier particles that are suspended in a background of free, unbound fluorescent sources. We have demonstrated the feasibility of our technique using a gentamicin competitive assay as well as idealized model systems. We have seen that the(More)
In a previous article a theory for detector response in fields of fast neutrons was presented. In the present paper this theory is subjected to experimental tests. For detectors of sizes comparable to the ranges of the neutron produced charged particles the theory predicts the variation of the detector response with detector size and elemental composition(More)
The form of a general theory of cavity ionisation is outlined and its applications to alpha-particle fields considered. The attenuation of the alpha particles within the cavity, which gives rise to the weighting factor in general cavity theory, is considered in detail and an appropriate treatment for alpha-particle fields developed. Apparatus, consisting of(More)
In vitro and in vivo indicator-dilution measurements are made with a fluorescent indicator and a novel detection system using a catheter containing a single optical fiber that carries both the exciting and returning fluorescent light. These fluorescent-dilution measurements are compared with simultaneous green dye-dilution measurements. The(More)
The site survey for the Advanced Technology Solar Telescope concluded recently after more than two years of data gathering and analysis. Six locations, including lake, island and continental sites, were thoroughly probed for image quality and sky brightness. The present paper describes the analysis methodology employed to determine the height stratification(More)
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