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BACKGROUND Genome-wide measures of gene expression can identify patterns of gene activity that subclassify tumours and might provide a better means than is currently available for individual risk assessment in patients with lymph-node-negative breast cancer. METHODS We analysed, with Affymetrix Human U133a GeneChips, the expression of 22000 transcripts(More)
BACKGROUND Published prognostic gene signatures in breast cancer have few genes in common. Here we provide a rationale for this observation by studying the prognostic power and the underlying biological pathways of different gene signatures. METHODS Gene signatures to predict the development of metastases in estrogen receptor-positive and estrogen(More)
We have analyzed the DNA copy numbers for over 100,000 single-nucleotide polymorphism loci across the human genome in genomic DNA from 313 lymph node-negative primary breast tumors for which genome-wide gene expression data were also available. Combining these two data sets allowed us to identify the genomic loci and their mapped genes, having high(More)
The brain is largely protected from damage due to infection, trauma, and aberrant processes by the innate immune system. These studies were undertaken to determine whether neurons in normal brains constitutively express complement components. In situ hybridization and immunohistochemical studies with specific riboprobes and antibodies, respectively,(More)
guidance, encouragement, and support in my graduate study. His knowledge, kindness, patience, enthusiasm, and vision have brought out the best from me in my M.S. and Ph.D. study and provided me with lifetime benefits. He teaches me how to create valuable ideas, perform research, communicate efficiently, and work with team members. I feel very fortunately to(More)
Our long-term goal is to develop improved hearing aids for people suffering from sensorineural hearing impairments. Our efforts are focused on problems resulting from inadequate knowledge of the effects of various alterations of speech signals on speech reception by impaired listeners, specifically on the fundamental limitations on the improvements in(More)
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