Jack Wittenberg

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An ultrasmall superparamagnetic iron oxide (USPIO) preparation was developed that is small enough to migrate across the capillary wall, a prerequisite in the design of targetable particulate pharmaceuticals. Seventy percent of particles were smaller than 10 nm; 26%, smaller than 5 nm. The blood half-life of USPIO in rats was 81 minutes, considerably longer(More)
Superparamagnetic iron oxide (ferrite) particles were evaluated as a contrast agent for magnetic resonance (MR) imaging. In this pilot study, doses ranging from 10 to 50 mumol/kg were administered intravenously to 15 patients. Ferrite-enhanced images of the liver obtained with standard pulse sequence techniques significantly increased the number of hepatic(More)
An ultrasmall superparamagnetic iron oxide (USPIO) preparation was evaluated as a potential intravenous contrast agent for lymph nodes. Relaxation time measurements and magnetic resonance (MR) imaging were performed in rats with normal lymph nodes and in rats with lymph node metastases. In normal animals, lymph node relaxation times decreased maximally(More)
To study the accuracy of preoperative staging techniques for assessing resectability of pancreatic and ampullary adenocarcinoma, we entered 88 consecutive candidates into a prospective study of contrast-enhanced computed tomography, magnetic resonance imaging, angiography, and laparoscopy. Resectability was proved in 16 (29%) of 55 patients for the head of(More)
Computed tomography demonstrates intestinal wall abnormalities that can be analyzed by categorizing attenuation changes in the intestinal wall and transposing morphologic characteristics learned from barium studies. These attenuation patterns include white, gray, water halo sign, fat halo sign, and black. The white pattern represents avid contrast material(More)
A combination of computed tomography, ultrasonography, and fluoroscopy was utilized to guide percutaneous catheter drainage of 58 abscesses and fluid collections in 51 patients. Cavities were evacuated in 53 cases, with surgery avoided in 44 of these. There were two failures and six recurrences. The mean duration of catheter drainage was seven days. Five(More)
PURPOSE To determine the changes in the computed tomographic (CT) appearance of primary epiploic appendagitis. MATERIALS AND METHODS Clinical records and CT scans were reviewed in 10 patients who were initially suspected of having diverticulitis or appendicitis but were later determined to have primary epiploic appendagitis. The scans were obtained at the(More)
OBJECTIVE Dilatation of the small bowel is a common finding on plain abdominal radiographs. In such cases, it is often difficult to determine if the cause of the dilatation is small-bowel obstruction, paralytic ileus, or another intraabdominal disorder. Accordingly, we studied the efficacy of CT in making this distinction. MATERIALS AND METHODS The(More)
OBJECTIVE To describe a new CT sign of the GI tract: the small bowel faeces sign, and discuss its significance. METHODS The small bowel faeces sign consists of gas bubbles mixed with particulate matter in dilated segments of small bowel. This was a retrospective study of 22 patients demonstrating this sign from 1989 to 1993. Final diagnosis was(More)
Follow-up of 13 patients who underwent radiologically guided percutaneous needle aspiration of simple liver cysts revealed cyst recurrence in all patients within 2 years. While still effective as a primary diagnostic maneuver, percutaneous aspiration seems to lack permanent therapeutic benefit. However, it may be used as a therapeutic trial to confirm the(More)